Texas A&M University-Kingsville

Personnel Profile

Dr. Peter Davies, Co-Director of the NNTRC for Translational Research

Peter Davies.png

Dr. Peter Davies is a distinguished pharmacologist and molecular endocrinologist. Prior to accepting the position of NNTRC Co-director for Translational Research, Dr. Davies has served as the Co-Director of the John S. Dunn Gulf Coast Consortium for Chemical Genomics since its inception in 2003. In addition, he serves as a member of the Oversight Committee of the Gulf Coast Consortia and as chair of the Research Consortia Committee. Dr. Davies is a Professor and Alkek Chair, the Director of the Center for Translational Cancer Research, and Executive Director of the Institute of Biosciences and Technology for Texas A&M Health Science Center. Previously, Dr. Davies was a Professor in Medicine and served as the Provost and Executive Vice-President for Research at UTHealth. The author of more than 130 peer-reviewed publications, Dr. Davies’ scientific interests have included extensive studies on the molecular basis of hormone and drug action with a particular emphasis on the biology and pharmacology of retinoids.

Education

• Cornell University, Ithaca, New York, B.A.

• University of Miami, Miami, Florida, M.D.

• University of Miami, Miami, Florida, Ph.D.

Appointments and Professional Service

Academic Appointments

  • Professor of Medicine, Division of Endocrinology, Department of Internal Medicine, University of Texas Medical School at Houston, 2011
  • Provost and Executive Vice President for Research, University of Texas Health Science Center at Houston, 2010 - 2011
  • Director, Translational Technologies and Core Resources, University of Texas Health Science at Houston, 2006 - 2010
  • Executive Vice President for Research, University of Texas Health Science Center at Houston, 2003 - 2010
  • Assistant Vice President for Research, University of Texas Health Science Center at Houston, 2001 - 2003
  • Director Genomics/Proteomics Research Core Laboratories, University of Texas Medical School at Houston, 2001 - 2006
  • Director M.D./Ph.D. Program, University of Texas Health Science Center at Houston, 1983 - 1993
  • Professor of Pharmacology and Medicine, University of Texas Medical School at Houston, 1987 - present
  • Associate Professor of Pharmacology and Medicine, University of Texas Medical School at Houston, 1984 - 1987
  • Assistant Professor of Medicine, University of Texas Medical School at Houston, 1982 - 1984
  • Assistant Professor of Pharmacology, University of Texas Medical School at Houston, 1979 - 1984

Non-Academic Appointments

  • Director, Gulf Coast Consortia CPRIT High Throughput Screening Program - Gulf Coast Consortium Universities, 2011 - present
  • Director, John S. Dunn Gulf Coast Consortium for Chemical Genomics, Gulf Coast Consortium Universities, 2004 - present
  • Consultant, Ligand Pharmaceuticals, Inc., San Diego, California, 1997 - 2003
  • Consultant, Allergan/Ligand Retinoid Technologies, Inc., San Diego, California 1994 - 1997
  • Senior Scientific Investigator (part-time), Retinoid Program, Allergan/Ligand Joint Venture, Irvine, California, 1992 - 1994

Committee Activities

COMMITTEES – DEPARTMENT OF INTEGRATIVE BIOLOGY AND PHARMACOLOGY (Preceding 5 years):
  • Faculty Search Committee (2008 – 2009)

COMMITTEES – UNIVERSITY OF TEXAS MEDICAL SCHOOL AT HOUSTON (Preceding 5 years):
  • MD/PhD Committee (1997 – 2007)

COMMITTEES – UNIVERSITY OF TEXAS HEALTH SCIENCES CENTER AT HOUSTON (Preceding 5 years):
  • Committee for the Protection of Human Subjects (ex officio) (2001- 2011)
  • Intellectual Property Committee (ex officio) (2001- 2011)
  • Information Technology Governance Committee (2005 – 2011)
    • Research Subcommittee co-chair (2007 – 2008)
  • Executive Council (2003 – 2011)
  • Executive Budget Committee (2004 – 2011)
  • Compensation Committee 2004 – 2007
  • Research Conflict of Interest Committee (ex officio) (2001- 2011)
  • Research Council (2004 – 2011)
  • Executive Compliance Committee (2004 – 2011)
  • Alliance for Nanohealth Steering Committee (2005 – 2011)
  • Space Planning Committee (2006 – 2011)
  • UT/TIRR Oversight Committee (2006 – 2011)
  • Human Embryonic Stem Cell Oversight Committee (ex officio) (2006 – 2011)
  • Endowment Compliance Committee (2007 – 2011)
  • Legislative Working Group Committee (2008 – 2011)
  • Univ of Texas Research Park Governance Council
  • Center for Advanced Biomedical Imaging Research (CABIR)
    • Executive Committee (2007 – 2011)
    • Operating Committee (2007 – 2011)
  • Chair, Dental Branch Dean Search Committee (2010 – 2011)
  • Graduate School of Biomedical Sciences Dean Search Committee (2010 – 2011)

COMMITTEES – UNIVERSITY OF TEXAS SYSTEM (Preceding 5 years):
  • TxAN Texas Alliance for Nanotechnology (2008 - 2011)
  • U.T. System Institutional Review Board (IRB) Task Force – Co-chair (2008 – 2009)
  • U.T.. System Research Collaborations Initiative Task Force (2007)
  • U.T.. System Technology Commercialization Symposium Steering Committee (2010 - 2011)
  • U.T.. System Search Committee – Associate Vice Chancellor for Research (2010)

COMMITTEES – HOUSTON AND TEXAS (Preceding 5 years):
  • HAM-TMC Library Board (2009- )
  • Texas – United Kingdom Collaborative Research Institute Board (2007 - )
  • Texas Southern University – Research Centers in Minority Institutions – External Advisory Board (2008 - ) Gulf Coast Consortium
    • Oversight Committee – Vice Chair (2011 - )
  • Oversight Committee (2003 - 2011)
    • Research Committee – Co-chair (2005 - 2008)
    • Research Committee – Chair (2008 - )
    • Chemical Genomics Consortium Board (2005 - )
  • Rice University Collaborative Research Center (CRC) –Steering Committee
  • Alliance for NanoHealth
  • Steering Committee Member (2005 - 2011)
  • Steering Committee Chair (2008 - 2011)
  • University of Texas El Paso Search Committee – Dean of Natural Sciences - member (2007)

COMMITTEES – NATIONAL AND INTERNATIONAL ORGANIZATIONS (Preceding 5 years):
  • Association of Academic Health Centers
    • HIPAA Workgroup 2008
    • Program Committee – Chair (2008 - 2011)
  • American Association of Medical Colleges (AAMC)
  • Program Committee (2008 - 2011)
  • Howard Hughes Medical Institute
    • Research Training Fellowship Review Panel (2007 – 2009)
    • Physician – Scientist Early Career Award Review Panel
    • Wyeth Pharmaceuticals Annual Therapeutic Options for Menopausal Health Conference
      • Program Committee – Member (2007 – 2010)
      • - Co-Chair (2009)

Awards And Honors

  • Dean's Teaching Excellence - 5 Year Award (1983-1988)
  • Marsh Memorial Lectureship, University of Miami, Dept. of Biochemistry, 1984
  • Established Investigator, American Heart Association, 1984-1989
  • Pfizer Lecturer, Clinical Research Institute of Montreal, Feb. 1987
  • Member Internal Advisory Committee of the Diabetes and Endocrinology Research Center, Baylor College of Medicine, 1987-1990
  • FASEB Conference on Retinoids
       Vice-Chairman, 1990
       Chairman, 1992
  • Texas Affiliate, American Heart Association-
       Member, Board of Directors, 1988-1993
       Chairman, Research Appropriation & Allocation Committee, 1988-1990
       Vice-President, 1991-1992
       President-Elect, 1992-1993
       President, 1993-1994
  • 1st International Conference on Transglutaminases and Protein Cross-Linking Reaction, Miami, FL. Conference Chairman, 1987.
  • 2nd International Conference on Transglutaminases and Protein Cross-Linking Reaction, Cannes France Conference Chairman, 1990.
  • 4th International Conference on Transglutaminases and Protein Cross-Linking Reaction, Debrecen, Hungary Organizer, 1994.
  • Doctor Honoris Causa University Medical School of Debrecen, Debrecen Hungary October, 1998
  • Deans Excellence in Teaching Award (5-year award) 2001
  • Elected Member of the University of Texas Academy of Health Science Educators, May 2011
  • University of Texas School of Nursing Commencement Speaker, May 2011

Review Articles

  1. Senn H.V. and Davies P.J.A. Optical rectification and gridding of satellite photographs. J. Applied Meteorol. 5:334-339, 1966.
  2. Mills T.M., Davies P.J.A. and Savard K. Stimulation of estrogen synthesis in rabbit follicles by luteinizing hormone. Endocrinology 88:857-862, 1971.
  3. LeMaire W., Davies P.J.A. and Marsh J. The role of prostaglandins in the development of refractoriness to LH stimulation by graafian follicles. Prostaglandin 12:271-279, 1976.
  4. Shizuta Y., Davies P.J.A., Olden K. and Pasta I. Diminished content of plasma membrane-associated myosin in transformed fibroblasts. Nature 261:414-415, 1976.
  5. Shizuta Y., Shizuta H., Gallo G., Davies P. and Pasta I. Purification and properties of filamin, and actin binding protein from chicken gizzard. J. Biol. Chem. 251:6562-6567, 1976.
  6. Davies P., Wallach D., Willingham M., Pasta I., Yamaguchi M. and Robson R.M. Ca+2-Activated proteolysis of filamin dissociates actin binding from gelatin. J. Biol. Chem. 253:4036-4042, 1976.
  7. Wallach D., Davies P. and Pasta I. Purification of mammalian filamin: similarity of high molecular weight actin binding protein in macrophages, platelets, fibroblasts and other tissues. J. Biol. Chem. 253:3328-3335, 1976.
  8. Davies P., Shizuta Y., Olden K., Gallo M. and Pasta I. Phosphorylation of filamin and other proteins in cultured fibroblasts. Biochem. Biophys. Res. Commun. 74:300-307, 1977.
  9. Davies P., Bechtel P. and Pasta I. Filamin inhibits actin activation of heavy meromyosin ATPase. FEBS Lett. 77:228-232, 1977.
  10. Wallach D., Davies P., Bechtel P., Willingham M. and Pasta I. Cyclic AMP-dependent phosphorylation of the actin-binding protein filamin. Adv. Cyclic Nucleo. Res. 9:371-379, 1978.
  11. Wallach D., Davies P.J.A. and Pastan I. Cyclic AMP-dependent phos-phorylation of filamin in mammalian smooth muscle. J. Biol. Chem. 253:4739-4745, 1978.
  12. Maxfield F.R., Willingham M.C., Davies P.J.A. and Pastan I. Receptor-mediated endocytosis in cultured fibroblast: amines inhibit clustering of 2-Macroglobulin and EGF on the cell surface. Nature 277:661-663, 1979.
  13. Richert N.D., Davies P.J.A., Jay G.W.H. and Pastan I. Characterization of an immune complex kinase in immunoprecipitates of avian sarcoma virus transformed fibroblasts. J. Virol. 31:695-706, 1979.
  14. Richert N.D., Davies P.J.A., Jay G.W.H. and Pastan I. Inhibition of the transformation-specific kinase in ASV transformed cells by N--Tosyl-L-Lysyl-Chloromethyl Ketone. Cell 18:369-374, 1979.
  15. Maxfield F.R., Willingham M.C., Schlessinger J., Davies, P.J.A. and Pastan I.: Receptor-mediated internalization of proteins and polypeptide hormones by cultured fibroblasts. In: Hormones and Cell Culture Cold Spring Harbor Conferences on Cell Proliferation, Vol. 6., p. 159-166, 1979.
  16. Pastan I., Jay G.W.H., Richert M.D., Davies P.J.A. and Willingham M.C.: The Nature and intracellular location of the product of the SRC gene of avian sarcoma virus. Cold Spring Harbor, 44(P2): 1023-1029, 1979.
  17. Maxfield F.R., Davies P.J.A., Klempner L., Willingham M.C. and Pastan I. Transglutaminase inhibitors prevent the clustering and internalization of epidermal growth factor and potentiate the stimulation of DNA synthesis. Proc. Nat. Acad. Sci., USA 76:5731-5735, 1979.
  18. Davies P.J.A., Chabay R., Zech L.A., Berman M. and Pastan I. Prostaglandin E binding and adenylate cyclase activation in normal and transformed fibroblasts. Biochim. Biophys. Acta 629:282-291, 1980.
  19. Davies P., Wallach D., Pastan I. and Lewis M.S. Aggregation properties of chicken gizzard filamin and heavy merofilamin. Biochemistry 19:1366-1372, 1980.
  20. Davies P.J.A., Davies D., Maxfield F.R., Levitzki A., Milhaud P., Willingham M.C. and Pastan I. Evidence that transglutaminase plays an essential role in receptor-mediated endocytosis. Nature 283:162-167, 1980.
  21. Milhaud P.G., Davies P.J.A., Pastan I. and Gottesman M.M. Regulation of transglutaminase activity in Chinese hamster ovary cells. Bio-chem. Biophys. Acta 630:476-484, 1980.
  22. Baldwin D., Prince M., Marshall S., Davies P. and Olefsky L.M. Regulation of insulin receptors: evidence for involvement of an endocytotic internalization pathway. Proc. Nat. Acad. Sci. USA 77:5975-5978, 1980.
  23. Willingham M.C., Yamada S.S., Davies P.J.A., Rutherford A.V., Gallo M.G. and Pastan I. The intracellular localization of actin in cultured fibroblasts by electron microscopic immocytochemistry. J. Histochem. Cytochem. 29:17-37, 1981.
  24. Moake J.L., Tang S.S., Olson J.D., Troll J.H., Cimo P.L., and Davies P.J.A. Platelets, von Willebrand factor and prostaglandin I2. Amer. J. Physiol. 241:H54-H59, 1981.
  25. Davies P.J.A. and Klee C. Calmodulin Acceptor Proteins. Identification of a high molecular weight calmodulin acceptor protein from bovine brain. Biochem. Internat. 3:203-212, 1981.
  26. Evans R.M., Davies P.J.A. and Costa M. Video time lapse microscopy of phagocytosis and intracellular fate of crystalline nickel sulfide particles in cultured mammalian cells. Cancer Res. 42:2729-2735, 1982.
  27. Murtaugh M.P., Steiner A.L. and Davies P.J.A. Localization of the catalytic subunit of cyclic AMP dependent protein kinase in cultured cells using a specific antibody. J. Cell Biol. 95:64-72, 1982.
  28. Amoscato A.A., Davies P.J.A., Babcock G.F. and Nishioka K. Receptor mediated internalization of tuftsin by human polymorphonuclear leukocytes. J. Retic. Endo. Soc. 34:53-67, 1983.
  29. Cornwell M.M., Juliano R.L. and Davies P.J.A. Inhibition of the adhesion of CHO cells by the naphthylsulfonamides dansylcadaverine and W7. Biochim. Biophys. Acta 762:414-419, 1983.
  30. Murtaugh M.P., Mehta K., Juliano R.L. and Davies P.J.A. Induction of tissue transglutaminase in mouse peritoneal macrophages. J. Biol. Chem. 258:11074-11082, 1983.
  31. Davies P.J.A., Cornwell M.M., Johnson J.D., Regianni A., Myers M., and Murtaugh M.P. Studies on the effects of dansylcadaverine and related compounds on receptor mediated endocytosis in cultured cells. Diabetes Care 7:Suppl 1. 35-41, 1984.
  32. Mehta K., Juliano R.J., Murtaugh M.P. and Davies P.J.A. Phagocytosis inhibits the expression of tissue transglutaminase in mouse peritoneal macrophages. J. Immunol. 132:2552-2558, 1984.
  33. Murtaugh M.P., Arendt W.P. and Davies P.J.A. Induction of tissue transglutaminase in human peripheral blood monocytes. J. Exp. Med. 159:114-125, 1984.
  34. Davies P.J.A. and Murtaugh M.P. Transglutaminase and receptor mediated endocytosis in macrophages and cultured fibroblasts. Mol. Cell Biochem. 58:69-77, 1984.
  35. Moore W.T., Murtaugh M.P., and Davies P.J.A. Retinoic acid induced expression of tissue transglutaminase in mouse peritoneal macrophages. J. Biol. Chem. 259:12794-12802, 1984.
  36. Davies P.J.A., Moore W.T. and Murtaugh M.P. Retinoid regulated gene expression in normal and leukemic myeloid cells. Bioassays 1:160-165, 1984.
  37. Lucas D.L., Tanuma S., Davies P.J.A., Wright D.G. and Johnson G.S. Maturation of human promyelocytic leukemia cells induced by nicotinamide: Evidence of a regulatory role for ADP-ribosylation of chromosomal proteins. J. Cell Physiol. 121:334-340, 1984.
  38. Davies P.J.A., Murtaugh M.P., Moore W.T., Johnson G.S. and Lucas D. Retinoic acid-induced expression of tissue transglutaminase in human promyelocytic leukemia (HL-60) cells. J. Biol. Chem. 260:5166-5174, 1985.
  39. Mehta K., Lopez-Berestein G., Moore W.T. and Davies P.J.A. Interferon -requires serum retinoids to promote the expression of tissue transglutaminase in cultured human blood monocytes. J. Immunol. 134:2053-2056, 1985.
  40. Murtaugh M.P., Moore W.T. and Davies P.J.A. Cyclic AMP potentiates in retinoic acid-induced expression of tissue transglutaminase in peritoneal macrophages. J. Biol. Chem. 261:614-621, 1986.
  41. Murtaugh M.P., Dennison O., Stein J.P. and Davies P.J.A. Retinoic acid-induced expression of tissue transglutaminase mRNA in cultured mouse peritoneal macrophages. J. Exp. Med. 163:1325-1330, 1986.
  42. Johnson J.D. and Davies P.J.A. Pertussis toxin inhibits retinoic acid-induced expression of tissue transglutaminase in macrophages. J. Biol. Chem. 261:14982-14986, 1986.
  43. Chiocca E.A., Davies P.J.A. and Stein J.P. The molecular basis of retinoid action: Transcriptional regulation of tissue transglutaminase gene expression in macrophages. J. Biol. Chem. 263:11584-11589, 1988.
  44. Davies P.J.A., Chiocca E.A., Basilion J.P., Poddar S. and Stein J.P. Transglutaminases and their regulation: Implications for polyamine metabolism. In: Polyamines in Biochemical and Clinical Research, (V. Zappia, ed.) Plenum Press, pp. 391-401, 1988.
  45. Davies P.J.A., Chiocca E.A. and Stein J.P.: Retinoid-regulated expression of tissue transglutaminase in normal and leukemic myeloid cells. In: Advances in Post-Translational Modifications of Proteins and Aging, (V. Zappia, ed.) Plenum Press, pp. 63-71, 1988.
  46. Davies P.J.A., Basilion J.P., Chiocca E.A., Johnson J., Poddar S. and Stein J.P. Retinoids as generalized regulators of cellular growth and differentiation. A. J. Med. Sci. 31:164-170, 1988.
  47. Davies P.J.A., Basilion J.P., Chiocca E.A., Fung W.W., Duvic M. and Stein J.P.: Retinoid-regulated gene expression in normal and transformed cells: Transcriptional Activation of Tissue Transglutaminase Gene Expression. Pharmacology of Retinoids in the Skin, Karger Press, Vol 3, pp. 20-28, 1989.
  48. Chiocca E.A., Davies P.J.A. and Stein J.P. Regulation of tissue transglutaminase gene expression as a molecular model for retinoid effects on proliferation and differentiation. J. Cell. Biochem. 39:293-304, 1989.
  49. Gentile V., Saydak M., Chiocca E.A., Akande N., Birckbichler P.J., Lee K.N., Stein J.P. and Davies P.J.A. Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminase. J. Biol. Chem., 266:478-483, 1990.
  50. Fesus L., Nagy L., Basilion J.P. and Davies P.J.A. Retinoic acid receptor transcripts in human umbilical cells. BBRC 179(1):32-38, 1991.
  51. Fesus L., Davies P.J.A. and Piacentini M. Apoptosis: Molecular mechanisms in programmed cell death. Eur. J. Cell Biol. 56:170-177, 1992.
  52. Davies P.J.A., Stein J.P., Chiocca E.A., Basilion J.P., Gentile V., Thomazy V. and Fesus L. Retinoid-regulated expression of transglutaminases: links to the biochemistry of programmed cell death. Oxford University Press, In: Retinoids in Normal Development and Teratogenesis, 249-263, 1992.
  53. Gentile V., Thomazy V., Piacentini M., Fesus L. and Davies P.J.A. Expression of tissue transglutaminase in Balb-C 3T3 cells: Effects on cellular adhesion and apoptosis. J. Cell Biol., 119:463-474, 1992.
  54. Piacentini M., Ceru M.P., Dini lL., DiRao M., Piredda L., Thomazy V., Davies P.J.A. and Fesus L. In vivo and in vitro induction of tissue transglutaminase in rat hepatocytes by retinoic acid and its effect on apoptosis. Biochim. Biophys. Acta 1135:171-179, 1992.
  55. Schroeder W.T., Thacher S.M., Stewart-Galetka S., Tang H.-Y., Gentile V., Siciliano M.J., Davies P.J.A. and Duvic M. Type I human keratinocyte transglutaminase cDNA assigned to chromosome 14 is more homologous to rabbit epithelial transglutaminase than to human tissue than transglutaminase. J. Inv. Derm., 99:27-34, 1992.
  56. Duvic M., Nelson D.C., Annarella M., Cho M., Esgleyes-Tibot T., Remenyik E., Ulmer R., Paini R.P., Sacks P.G., Clayman G.L., Davies P.J.A., and Thacher S. Keratinocyte Transglutaminase Expression Varies in Squamous Cell Carcinoma. J. of Investigative Dermatology, 102:462-469, 1994.
  57. Piacentini M., Davies P.J.A., and Fesus L. Tissue transglutaminase in cells undergoing apoptosis. Apoptosis II: The Molecular Basis of Apoptosis in Disease; Cold Spring Harbor Laboratory Press:143-163, 1994.
  58. Gentile V., Davies P.J.A. and Baldini A. The human tissue transglutaminase gene maps on chromosome 20q12 by in situ fluorescence hybridization. GENOMICS 20:295-297, 1994.
  59. Johnson T.S., Knight C.R.L., El-Alaoui S., Mian S., Rees R.C., Gentile V., Davies P.J.A., and Grinnin M. Transfection of tissue transglutaminase into a highly malignant hamster fibrosarcoma leads to a reduced incidence of primary tumour growth. Oncogene, 9:2935-2942, 1994.
  60. Beard R.L., Gil D.W., Marler D.K., Henry E., Colon D.F., Gillett S.J., Davies P.J.A., and Chandraratna R.A.S. Structural basis for the RXR activity of stilbene retinoid analogs. Bio. Organic in Medicinal Chem. Ltrs. Vol.4,#12, pgs. 1447-1452, 1994.
  61. Melino G., Annicchiarico-Petruzzelli M., Piredda L., Candi E., Gentile V., Davies P.J.A., and Piacentini M. Tissue transglutaminase and apoptosis: sense and antisense transfection studies in human neuroblastoma cells. Molec. & Cell. Biol., 14:6584-6596, 1994.
  62. McCormack S.A., Wang J-Y, Viar M.J., Tague L., Davies P.J.A., and Johnson L.R. Polyamines influence transglutaminase activity and cell migration in two cell lines. Amer. Phys. Soc., 267-36:C706-C714, 1994.
  63. Remenyik E., Davies P.J.A., and Duvic M. Skin-equivalent model. Borgogy. Vener. Szemle 71:19-24, 1994.
  64. Nagy L., Thomazy V., Davies P.J.A. Transglutaminases: Effecter Molecules in Physiologic Cell Death. The Cancer Bulletin, Vol. 46, No.2, 136-140.1994.
  65. Nagy L., Thomazy V.A., Shipley G.L., Fesus L., Lamph W., Heyman, R.A., Chandraratna, R.A.S., and Davies, P.J.A. Activation of retinoid X receptors (RXR) induces apoptosis in HL-60 cells. Mol. Cell. Biol., 15,7:3540-3551, 1995.
  66. Lu S., Chin K-V, Saydak M. Gentile V., Stein J.P., and Davies P.J.A. Isolation and characterization of the human tissue transglutaminase gene promoter and its regulation by P53. J. Biol. Chem., 270:9748-9756, 1995.
  67. Beard R.L., Chandraratna R.A.S., Colon D.F., Gillett S. J., Henry E., Marler D.K., Song T., Denys L., Garst M.E., Arefieg T., Klein E., Gil D.W., Wheeler L., Kochlar D.M., Davies P.J.A. Synthesis and structure activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. J. Med. Chem., 38(15):2820-2829, 1995.
  68. Shalinsky D.R., Gregory M.L., Bischoff E.D., Gottardis M.M., Hayes J.S., Lamph W.W., Heyman R.A., Shirley M.A., Cooke T., Davies P.J.A., and Thomazy V. Retinoid-induced suppression of squamous cell differentiation in human oral squamous cell carcinoma xenografts (line 1483) in athymic nude mice. Cancer Research, 55:3183-3191, 1995.
  69. Boehm M.F., Zhang L., Zhi L. McClurg M.R., Berger E., Wagoner M., Mais D.E., Suto C.M., Davies P.J.A., Heyman R.A., and Nadzan A.M. Design and synthesis of potent retinoid X receptor selective ligands which induce apoptosis in leukemia cells. J.Med.Chem., 38:3146-3155, 1995.
  70. Mian S., Alaoui S.El., Lawry J., Gentile V., Davies P.J.A., and Griffin M. The importance of the GTP binding protein tissue transglutaminase in the regulation of cell cycle progression. FEBS LETT 370:27-31, 1995.
  71. Nadzan A.M., Boehm M.F., Zhang L., Badea B.A., Zhi L., White S.K., Mais D.E., Berger E., Suto C.M., McClurg M.R., Davies P.J.A., and Heyman R.A. Design of novel RXR selective retinoids. E.J. Med.Chem., 30:519s-533s, 1995.
  72. Nagy L., Thomazy V.A., Heyman R.A., Chandraratna R.A.S., and Davies P.J.A. Retinoid-regulated expression of BCL-2 and tissue transglutaminase during the differentiation and apoptosis of human myeloid leukemia (HL-60) cells. Leukemia Res. Vol. 20, No. 6, pp. 499-505, 1996.
  73. Nagy L., Saydak M., Shipley N., Lu S., Basilion J.p., Yan Z.H., Syka P., Chandraratna R.A.S., Heyman R.A., Stein J.P., and Davies P.J.A. Identification and characterization of a versatile retinoid response element (RARE/RXRE) in the mouse tissue transglutaminase gene promoter. J.Biol.Chem., 271:4355-4365, 1996.
  74. Shalinsky D.R., Bischoff,E.D. Gregory M.L., Lamph W.W., Heyman R.A., Hayes J.S., Thomazy V. and Davies P.J.A. Enhanced antitumor efficacy of cisplatin in combination with ALRT1057 (9-cis retinoic acid) in human oral squamous carinoma xenografts in nude mice. Clin. Cancer Res., 2: 511-520, March 1996.
  75. Peluso G., Petilo O., Mazzarella L., La Cara F., Sada A., Melone M.A.B., Davies P.J.A. and Gentile V. Cell-biomaterial interactions: role of transglutaminase enzyme. Journal of Materials Science: Materials in Medicine 7, pp. 707-711, 1996.
  76. Nagy L., Thomazy V.A., Saydak M.M., Stein J.P., and Davies P.J.A. The promoter of the mouse tissue transglutaminase gene directs tissue-specific, retinoid-regulated and apoptosis-linked expression. Cell Death and Differentiation. 4, 534-547, 1997.
  77. Standeven A.M., Beard R.L., Johnson A.T., Boehm M.F., Escobar M., Heyman R.A. and Chadraratna R.A.S. Retinoid-induced hypertriglyceridemia in rats is mediated by retinoic acid receptors. Fund. Appl. Toxicol. 33(2):264-271, 1996.
  78. Nicholas B., Jones R., Mian S., Davies P.J.A. and Griffin M. Reduced expression of tissue transglutaminase in a human endothelial cell line leads to changes in cell spreading, cell adhesion and reduced polymerisation of fibronectin. J. Cell Science. 110, 2461-2472, 1997.M
  79. Piredda L., Amendola A., Colizzi V., Davies P.J.A., Grazia Farrace M., Fraziano M., Gentile V., Uray I., Piacentini M. and Fesus L. Lack of "tissue" transglutaminase protein cross-linking leads to leakage of macromolecules from dying cells: relationship to development of autoimmunity in MRLIpr/Ipr mice. Cell Death and Differentiation 4(6), 463-472, 1997.
  80. Yan Z.H., Noonan S., Nagy L., Davies P.J.A., and Stein J.P. Retinoic acid induced activation of the mouse tissue transglutaminase promoter is medicated by a novel tripartite response element. Mol. & Cell. Endo., 120(2), 203-212 , 1996.
  81. Klein E.S., Pino M.E., Johnson A.T., Davies P.J.A., Nagpal S., Thacher S., Krasinski, G. and Chandraratna R.A.S. Identification and functional Separation of retinoic acid receptor neutral antagonists and inverse agonists., J. Biol. Chem., Vol. 271, No. 37, September 13, 22692-22696, 1996.
  82. Remenyik E., Davies P.J.A., and Duvic M. Effect of fibroblasts on keratinocyte in skin equivalent model. Borgyogyaszati Es Veneroogiai Szemle 72. EVF. 2. 35-40.
  83. Standeven A.M., Davies P.J.A., Chandraratna R.A.S., Mader D.R., Johnson A.T., and Thomazy V.A. Retinoid-induced epiphyseal plate closure in guinea pigs. Fund. & Appl. Toxicol. 34, 91-98, 1996.
  84. Mirza A., Liu S-L, Frizell E., Zhu J., Maddukuri S., Martinez J., Davies P. Schwarting R., Norton P., and Zern M.A. A postulated role for tissue transglutaminase in hepatic fibrinogenesis, and its potential regulation by nuclear factor-kB (NF-kB). Amer. J. Physiology - Gastrointestinal & Liver Physiology, Vol. 272, pp G2181-G2188, 1997.
  85. Shalinsky D.R., Bischoff E.D., William W.L., Lamph L.Z., Boehm M.F., Davies P.J.A., Nadzan A.M., and Heyman R.A. A novel RAR-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice. Cancer Research, 57(1):162-168, 1996.
  86. Lippman S.M. and Davies P.J.A. "Retinoids, Neoplasia and Differentiation Therapy " Cancer Chemother Biol Response Modif 17:349 62, 1997.
  87. Davies Peter J.A. and Lippman S.M. Biologic basis of retinoid pharmacology: implications for cancer prevention and therapy. Adv. in Oncology, 12:2-10,1996.
  88. Balajthy Z., Kedei N., Nagy, Davies P.J.A., and Fesus L. Lack of induction of tissue transglutaminase but activation of the pre-existing enzyme in c-Myc-induced apoptosis of CHO cells. Biochem. and Biophysic. Res. Communications 236, 280-284, 1997.
  89. Gentile V., Porta R., Chiosi E., Spina A., Valente F., Pezone R., Davies P.J.A., Alaadik A. and Illiano G. tTGase/Gαh protein expression inhibits adenylate cyclase activity in Balb-C 3T3 fibroblasts membranes. Biochimica et Biophysica Acta - Molecule. Cell Res., 5; 1357(1), 115-122, 1997.
  90. Beard R.L., Colon D.F., Song T.K., Davies P.J.A., Kochhar D.M., and Chandraratna R.A.S. Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid. J. Med. Chem. Vol. 39, No. 18, pp 3556-3563, 1996.
  91. Lu S. and Davies P.J.A. Regulation of the expression of the tissue transglutaminase gene by DNA methylation. Proc. Natl. Acad. Sci. 94, 4692-4697, 1997.
  92. Mukherjee R., Davies P.J.A., Cesario R., Jow L., Crombie D., Hamann L.G., Boeohm M.F., Mondon C., Nadzan A.M., Paterniti Jr., J.R., and Heyman R.A. RXR agonists activate RXR:PPAR heterodimers and sensitive diabetic and obese mice to insulin. Nature Vol. 386, pp 407-410, 1997.
  93. Ritter S.J. and Davies P.J.A. Identification of a transforming growth factor-β1/bone morphogenetic protein 4 (TGFβ1/BMP4) response element within the mouse tissue transglutaminase gene promoter. J. Biological Chemistry, Vol. 273, No. 21, May 22, pp 12798-12806, 1998.
  94. Depre C., Shipley G.L., Chen W., Han Q., Ahuja,H.S., Stepkowski,S., Davies,P.J.and Taegtmeyer, H. Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nature Med. Nov.; 4(11):1269 75, 1998.
  95. Nagy L., Thomazy V.A. and Davies P.J.A. A transgenic mouse model for the study of apoptosis during limb development. Cell Death & Different. 5, 126, 1998.
  96. Nagy L., Thomazy V.A., Heyman R.A. and Davies P.J.A. Retinoid-induced apoptosis in normal and neoplastic tissues. Cell Death and Differentiation. 5, 11-19, 1998.
  97. Kuncio G.S., Tsyganskaya M., Zhu J., Liu S-L, Nagy L., Thomazy V.A., Davies P.J.A and Zern M. TNF- modulates expression of the tissue transglutaminase gene in liver cells. J. Amer. Physiological Society, G240-G245, 1998.
  98. Dupe V., Ghyselinck N.B., Nagy L., Davies P.J.A., Chambon P. and Mark M. Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods. Developmental biology. 208, 30-43, 1999.
  99. Thomazy V., Davies P.J.A. Expression of tissue transglutaminase in the developing chicken limit is associated both with apoptosis and endochondral ossification. Cell Death and Differentiation. 6, 146-154, 1999.
  100. Depre C., Young M.E., Ying J., Ahuja H.S., Han Q., Garza N., Davies P.J., Taegtmeyer H., Streptozotocin-induced changes in cardiac gene expression in the absence of severe contractile dysfunction. J Mol Cell Cardiol. Jun;32(6):985-96, 2000.
  101. Szegezdi E., Szondy Z., Nagy L., Nemes Z., Friis R.R., Davies P.J., Fesus L. Apoptosis-linked in vivo regulation of the tissue transglutaminase gene promoter. Cell Death Differ. Dec;7(12):1225-33, 2000.
  102. Juneja H.S., Lee S., Thomazy V., Shipley G., Davies P.J. Acute activation of gp130 gene expression in bone marrow stromal cells by contact with myeloma-derived lymphoblastic cell line ARH77 cell membranes. J Interferon Cytokine Res. Mar; 21(3):157-66, 2001.
  103. Ahuja H.S., Liu S, Crombie D.L., Boehm M., Leibowitz M.D., Heyman R.A., Depre C., Nagy L., Tontonoz P., Davies P.J. Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents. Mol Pharmacol. Apr;59(4):765-73, 2001.
  104. Davies P.J., Berry S.A., Shipley G.L., Eckel R.H., Hennuyer N., Crombie D.L., Ogilvie K.M., Peinado-Onsurbe J., Fievet C., Leibowitz M.D., Heyman R.A., Auwerx J. Metabolic effects of rexinoids: tissue-specific regulation of lipoprotein lipase activity. Mol Pharmacol. Feb; 59(2):170-6, 2001.
  105. Uray I.P., Davies P.J., Fesus L. Pharmacological separation of the expression of tissue transglutaminase and apoptosis after chemotherapeutic treatment of HepG2 cells. Mol Pharmacol. Jun;59(6):1388-94, 2001.
  106. Young M.E., Patil S., Ying J., Depre C., Ahuja H.S., Shipley G.L, Stepkowski SM, Davies PJ, Taegtmeyer H. Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart. FASEB J. Mar;15(3):833-45,2001.
  107. Citron B.A., SantaCruz K.S., Davies P.J., Festoff B.W. Intron-exon swapping of transglutaminase mRNA and neuronal Tau aggregation in Alzheimer's disease. J Biol Chem. Feb 2;276(5):3295-301, 2001.
  108. Uray I.P., Connelly J.H., Thomazy V., Shipley G.L., Vaughn W.K., Frazier O.H., Taegtmeyer H., Davies P.J. Left ventricular unloading alters receptor tyrosine kinase expression in the failing human heart. J Heart Lung Transplant 2002 21(7) Jul :771-82
  109. Razeghi P., Young M.E., Ying J., Depre C., Uray I.P., Kolesar J., Shipley G.L., Moravec C.S., Davies P.J., Frazier O.H., Taegtmeyer H. Downregulation of metabolic gene expression in failing human heart before and after mechanical unloading. Cardiology 2002;97(4):203-9.
  110. Citron B.A., Suo Z., SantaCruz K., Davies P.J., Qin F., Festoff B.W. Protein crosslinking, tissue transglutaminase, alternative splicing and neurodegeneration. Neurochem Int 2002; 40 (1): Jan ; 69-78
  111. Ahuja T.S., Gopalani A., Davies P.J. and Ahuja H. Metalloproteinase-9 Expression in Renal Biopsies with HIV – Associated Nephropathy. Nephron Clin Pract 95(3):c100-4, 2003.
  112. Moreno-Smith Myrthala, Shipley G.S., Stancel G.M., Davies P.J.A., Pickar J.H and Loose-Mitchell D.S. Regulation of PACAP receptor Type I (PAC1-R) mRNA by Estrogens in Human Endometrium. Endocrinology. Submitted
  113. Callaerts-Vegh1 Z., Pocius J.S., Michael L. H., Taffet G. E., Hartley C. J., , Evans K. L. J., Shipley G. L., Davies P. J. A., Cuba D. L., Gurji H. A., Entman M. L., Giles H. and Bond Richard A. Effects of different beta adrenoceptor ligands in mice with permanent occlusion of the coronary artery. Br. J. Pharmacol. 2003 138(8) Apr:1505-16
  114. Thomazy V.A., Luthra R, Uthman M.O., Davies P.J., Medeiros L.J. Determination of Cyclin D1 and CD20 mRNA Levels by Real-Time Quantitative RT-PCR from Archival Tissue Sections of Mantle Cell Lymphoma and Other Non-Hodgkin's Lymphomas. J Mol Diagn 2002 4(4) Nov :201-8
  115. Festoff B.W., SantaCruz K., Arnold P.M., Sebastian C.T., Davies P.J., Citron B.A. Injury-induced "switch" from GTP-regulated to novel GTP-independent isoform of tissue transglutaminase in the rat spinal cord. J Neurochem 2002 81(4) May:708-18
  116. Uray I.P., Connelly J.H., Frazier O.H., Taegtmeyer H. and. Davies P.J.A. Mechanical Unloading Increases Caveolin Expression in Failing Human Heart (2002) Cardiovascular Res. 2003 59(1) Jul:57-66
  117. Deng L., Shipley G.L., Loose-Mitchell D.S, Stancel G.M., Pickar J.H. and Davies P.J.A. Coordinate Regulation of the Production and Signaling of Retinoic Acid by Estrogen in the Human Endometrium (2002) J. Clin Endo Metab. 2003 88(5) May:2157-63
  118. Anakk S., Kalsotra A., Shen Q., Vu M.T., Staudinger, J.L., Davies, P.J.A. and Strobel H.W. Genomic Characterization and Regulation of CYP3a13: role of xenobiotics and nuclear receptors. FASEB J. 2003 17(12) Sep:1736-8
  119. Copland J.A., Davies, P.J., Luxon B. and Urban, R.J. The use of DNA microarrays to assess clinical samples. The transition from bedside to bench to bedside. (2002) Recent Progress in Hormone Research 2003 58:25-53
  120. Shen Q., Cline G., Shulman G., Leibowitz M., and Davies P.J.A. Effects of Rexinoids on Glucose Transport and Insulin-Mediated Signaling in Skeletal Muscles of Diabetic (db/db) Mice. J Biol Chem. 2004 May 7;279(19):19721-31
  121. Bailey CD, Graham RM, Nanda N, Davies PJ, Johnson GV. Validity of mouse models for the study of tissue transglutaminase in neurodegenerative diseases. Mol Cell Neurosci. 2004 Mar;25(3):493-503.
  122. Thomazy VA, Vega F, Medeiros LJ, Davies PJ, Jones D. Phenotypic modulation of the stromal reticular network in normal and neoplastic lymph nodes: tissue transglutaminase reveals coordinate regulation of multiple cell types. Am J Pathol. 2003 Jul;163(1):165-74.
  123. Ahuja HS, Szanto A, Nagy L, Davies PJ. The retinoid X receptor and its ligands: versatile regulators of metabolic function, cell differentiation and cell death. J Biol Regul Homeost Agents. 2003 Jan-Mar;17(1):29-45. Review.
  124. Williams ET, Leyk M, Wrighton SA, Davies PJ, Loose DS, Shipley GL, Strobel HW. Estrogen regulation of the cytochrome P450 3A subfamily in humans. J Pharmacol Exp Ther. 2004 Nov;311(2):728-35
  125. Szanto A, Narkar V, Shen Q, Uray IP, Davies PJ, Nagy L. Retinoid X receptors: X-ploring their (patho)physiological functions. Cell Death Differ. 2004 Dec;11 Suppl 2:S126-43. Review.
  126. Balint BL, Szanto A, Madi A, Bauer UM, Gabor P, Benko S, Puskas LG, Davies PJ, Nagy L. Arginine methylation provides epigenetic transcription memory for retinoid-induced differentiation in myeloid cells. Mol Cell Biol. 2005 Jul;25(13):5648-63.
  127. Deng, L., Broaddus, R.B., McCampbell, A., Shipley, G.L.. Loose, D.S., Stancel, G.M., Pickar, J.H. and Davies, P.J. Identification Of A Novel-Estrogen Regulated Gene (Eig121) That Is Over-Expressed In Type I But Down-Regulated In Type II Endometrial Cancer J. Clin. Cancer Res. 2005;11(23) December 1, 2005
  128. McCampbell, A. S., Broaddus, R. R., Loose, D. S., and P. J. A. Davies: Over expression of the IGF-I Receptor and activation of the AKT Pathway in Hyperplastic Endometrium. Clin Cancer Res., 12(21):6373-6378, 2006. (commentary Zhang, H. and D. Yee: Is the Type I Growth Factor Receptor a Therapeutic In Endometrial Cancer? Clin Cancer Res., 12(21):6323-6325, 2006.)
  129. McCampbell, A.S., Walker, C.L., Broaddus, R.R., Cook, J.D., and P.J.A. Davies: Developmental Reprogramming of IGF Signaling and susceptibility to Endometrial Hyperplasia in the Rat. Lab Invest. 2008 Jun; 88(6): 615-26. Epub 2008 Apr 21.
  130. Zhang Q, Shen Q, Celestino J, Milam MR, Westin SN, Lacour RA, Meyer LA, Shipley GL, Davies PJ, Deng L, McCampbell AS, Broaddus RR, Lu KH.: Enhanced Estrogen-Induced Proliferation in Obese Rat Endometrium. Am J Obstet Gynecol. 2009 Feb;200(2):186.e1-8.

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