Texas A&M University-Kingsville

Personnel Profile

Dr. Elda E. Sanchez, Assistant Professor & NNTRC Executive Co-Director



 -2004 - Ph.D., Toxinology

 Summa Cum Laude

 Universidad Central de Venezuela

 Caracas, Venezuela

 -1999 - M.S., Biology

 Texas A&M University - Kingsville

 Kingsville, Texas


 Editorial Boards:

 -Revista de la Facultad de Medicina- Universidad Central de Venezuela, Caracas, Venezuela


 -2013 - Present

 Executive Co-Director, NNTRC

 Texas A&M University - Kingsville

 -2011 - 2012

 Interim Director, NNTRC

 Texas A&M University - Kingsville

 -2010 - Present

 Assistant Professor, Department of Chemistry

 Texas A&M University - Kingsville

 -2003 - 2011

 Assistant Director, NNTRC, TAMUK

 -1996 - 2003

 Laboratory Director, NTRC

 Texas A&M University - Kingsville

 -1994 - 1996   

 Graduate Research Assistant, NIH/MBRS Program

 Texas A&M University - Kingsville

 -1990 - 1993

 Undergraduate Research Assistant, NIH/MBRS Program

 Texas A&I University

 -1993 - B.S., Biology

 Cum Laude

 Texas A&I University -Kingsville

 Kingsville, Texas


 -Hall of Fame of Y Women In Careers (2012)

 -Minority Access, Inc., National Role Model Alumna Award (2005)

 -The Natural Toxins Research Center’s Commitment and Scientific Contribution Award (2005)

 -Graduated with honors (Summa Cum Laude, 2004, Ph.D.)

 -Women’s Center Bridging the GAP Award (March 1998)

 -NIH-AAMC-SACNAS Biomedical Research Poster Session Award (October 1997)

 -Biology Department Bogusch Memorial Scholarship recipient (1993)

 -Graduated with honors (Cum Laude, 1993, B.S.) •

 -National Hispanic Scholarship Fund recipient (1991, 92, 93)

 -Ed Rachel Scholarship recipient (4 yrs)

Invited Presentations

  1. Hall of Fame of Y Women In Careers (2012)
  2. Minority Access, Inc., National Role Model Alumna Award (2005)
  3. The Natural Toxins Research Center’s Commitment and Scientific Contribution Award (2005)
  4. Graduated with honors (Summa Cum Laude, 2004, Ph.D.)
  5. Women’s Center Bridging the GAP Award (March 1998)
  6. NIH-AAMC-SACNAS Biomedical Research Poster Session Award (October 1997)
  7. Biology Department Bogusch Memorial Scholarship recipient (1993)
  8. Graduated with honors (Cum Laude, 1993, B.S.) • National Hispanic Scholarship Fund recipient (1991, 92, 93)
  9. Ed Rachel Scholarship recipient (4 yrs)


  1. Lucena, S.E., Jia, Y., Soto, J.G., Parral, J., Cantu, E., Brannon, J., Lardner, K., Ramos, C.J., Seoane, A.I., Sánchez, E.E.* (2012) Anti-invasive and anti-adhesive activities of recombinant disintegrin, r-viridistatin 2, derived from the Prairie rattlesnake (Crotalus viridis viridis). Toxicon 60, 31-39.
  2. Massey, D.J., Calvete, J.J., Sánchez, E.E.*, Sanz, L, Richards, K., Curtis, R., Boesen, K. (2012) Venom variability and envenoming severity outcomes of the Crotalus scutulatus scutulatus (Mojave rattlesnake) from Southern Arizona. J Proteomics (In press).*Corresponding Author
  3. Barrios, M., Taylor, P., Rodríguez-Acosta, A., Sánchez, E.E., Arocha-Pinango, C.L., Gil, A., Salazar A.M., Carvajal, Z., Abad, M.J., Guerrero, B. (2012) A mouse model to study the alterations in haemostatic inflammatory parameters induced by Lonomia achelous caterpillar haemolymph. Toxicon 59, 547-554.
  4. Calvete, J.J., Pérez, A., Lomonte, B., Sánchez, E.E., Sanz L. (2012) Snake venomics of Crotalus tigris: The minimalist toxin arsenal of the deadliest neartic rattlesnake venom. Evolutionary clues for generating a Pan-specific antivenom against Crotalid type II venoms. J Proteome Res. 11, 1382-1390.
  5. Carey, C.M., Bueno, R., Gutierrez, D.A., Petro, C., Lucena, S.E., Sánchez, E.E., Soto, J.G. (2012) Recombinant rubistatin (r-Rub), an MVD disintegrin, inhibits cell migration and proliferation, and is a strong apoptotic inducer of the human melanoma cell line SK-Mel-28. Toxicon 59, 241-248.
  6. Khunsap, S., Pakmanee, N., Khow, O., Chanhome, L., Sitprija, V., Suntravat, M., Lucena, S.E., Perez, J.C., Sánchez, E.E.* (2011) Purification of a phospholipase A2 from Daboia russelii siamensis venom with anticancer effects. J Venom Res. 2, 42-51.*
  7. Bohlen, C.J., Chesler, A.T., Sharif-Naeini, R., Medzihradszky, K.F., Zhou, S., King, D., Sánchez, E.E., Burlingame, A.L., Allan I. Basbaum, A.I., Julius, D. (2011) A Heteromeric toxin from Texas coral snake targets acid-sensing ion channels to produce pain. Nature. 479, 410-414.
  8. Sánchez, E.E., Hotle, D., Rodríguez-Acosta, A. (2011) Neutralization of Bitis parviocula (Ethiopian Mountain Adder) Venom by the South African Institute of Medical Research (SAIMR) Antivenom. Revista do Instituto de Medicina Tropical de São Paulo (In Press).
  9. Guerrero, B., Arocha-Piñango, C.L., Salazar, A.M., Gil, A., Sánchez, E.E., Rodríguez-Acosta, A., Lucena, S. (2011) The effects of Lonomin V, a toxin from the caterpillar (Lonomia achelous), on hemostasis parameters as measured by platelet function. Toxicon (In Press).
  10. Salazar, A.M., Vivas, J., Sánchez, E.E., Rodríguez-Acosta, A., Ibarra, C., Gil, A., Carvajal, Z., María E. Girón, M.E., Estrella, A., Navarrete, L.F., Guerrero, B. (2011) Hemostatic and toxicological diversities in venom of Micrurus tener tener, Micrurus fulvius fulvius and Micrurus isozonus coral snakes. Toxicon (In Press).
  11. Lucena, S., Sanchez, E.E., Perez, J.C. (2011) Anti-metastatic Activity of the Recombinant Disintegrin, r-Mojastin 1, from the Mohave Rattlesnake. Toxicon 57, 794-802.
  12. Teklemariam, T., Seoane, A.I., Ramos, C.J., Sanchez, E.E., Lucena, S.E., Perez, J.C., Mandal, S.A., Soto, J.G. (2011) Functional analysis of a recombinant PIII-SVMP, GST-acocostatin; an apoptotic inducer of HUVEC and HeLa, but not SK-Mel-28 cells. Toxicon 57, 646-656.
  13. Girón, M.E., Estrella, A., Sánchez, E.E., Galán, J., Tao, W.A., Guerrero, B., Salazar, A.M., Rodríguez-Acosta, A. 2011. Purification and characterization of a metalloproteinase, Porthidin-1, from the venom of Lansberg's hog-nosed pitvipers (Porthidium lansbergii hutmanni). Toxicon 57, 608-618.
  14. Estrella, A.†, Sánchez, E.E.†, Galán, J.A., Tao, W.A., Guerrero, B., Navarrete, L.F., Rodríguez-Acosta, A. (2010) Characterization of toxins from the broad-banded water snake Helicops angulatus (Linnaeus, 1758): isolation of a cysteine-rich secretory protein. Arch Toxicol. 85, 305-313. †Authors contributed equally.
  15. Rodriguez-Acosta, A.†, Sánchez, E.E.†, Marquez, A., Salazar, A.M., Giron, M.E., Caravajal, Z., Gil, A., Guerrero, B. (2010) Hemostatic properties of Venenzuelan Bothrops snake venoms with special references to Bothrops isabelae venom. Toxicon 56, 926-935. †Authors contributed equally.
  16. Sánchez, E.E., Lucena, S.E., Reyes, S., Soto, J.G., Cantu, E., Lopez-Johnston, J.C., Guerrero, B., Salazar, A.M., Rodríguez-Acosta, A., Galán, J.A., Tao, W.A., Pérez, J.C. (2010). Cloning, expression, and hemostatic activities of a disintegrin, r-mojastin 1, from the Mohave rattlesnake (Crotalus scutulatus scutulatus). Thrombosis Research 126, e211-e219.
  17. Sánchez, E.E., Rodriguez-Acosta, A., Cantu, E., Guerrero, B. (2010) Antivenoms and Coagulation. In: Kini, R.M., McLane, M.A., Clemetson, K., Markland, F.S., Morita, T., (Eds.), Toxins and Hemostasis From Bench to Bedside, Springer, Dordrecht Heidelberg London New York, pp. 711-721.
  18. Rodriguez-Acosta, A., Guerrero, B., Sánchez, E.E. (2010) The theory of intraspecies variation is not the exception, but simply the rule: the diverse hemostatic activities of snake venoms. In: Kini, R.M., McLane, M.A., Clemetson, K., Markland, F.S., Morita, T., (Eds.), Toxins and Hemostasis From Bench to Bedside, Springer, Dordrecht Heidelberg London New York, pp. 97-112.
  19. Seoane, A.I., Tran, V.L., Sanchez, E.E., White, S.A., Choi. J.L., Gaytán, B., Chavez, N., Reyes, S.R., Ramos, C.J., Tran, L.H., Lucena, S.E., Sugarek, M., Perez, J.C., Mandal, S.A., Ghorab, S, Rodriguez-Acosta, A., Fung, B.K., Soto, J.G. (2010) The mojastin mutant Moj-DM induces apoptosis of the human melanoma SK-Mel-28, but not the mutant Moj-NN nor the non-mutated recombinant Moj-WN. Toxicon 56, 391-401.
  20. Gracheva, E.O., Ingolia, N.T., Kelly, Y.M., Cordero-Morales, J.F., Hollopeter, G., Chesler, A.T., Sánchez, E.E., Perez, J.C., Weissman, J.S., Julius, D. (2010) Molecular basis of infrared detection by snakes. Nature 464, 1006-1011.
  21. Guerrero, B., Finol, H.J., Reyes-Lugo, M., Salazar, A.M., Sánchez, E.E., Estrella, A., Roschman-González, A., Ibarra, C., Salvi, I., Rodríguez-Acosta, A. (2010) Activities against hemostatic proteins and adrenal gland ultrastructural changes caused by the brown widow spider Latrodectus geometricus (Araneaea: Theridiide) venom. Comp Biochem Physiol, C Toxicol Pharmacol. 151, 113-121.
  22. Reyes-Lugo, M., Sánchez, T., Finol, H.J., Sánchez, E.E., Suárez, J.A., Guerrero, B., Rodríguez-Acosta, A. (2009) Neurotoxic activity and ultrastructural changes in muscles caused by the brown widow spider Latrodectus geometricus Koch, 1841 (Araneae: Theridiidae) venom. Revista do Instituto de Medicina Tropical de São Paulo Rev. Inst. Med. Trop. S. Paulo. 51, 95-101.
  23. Jia, Y., Lucena, S., Cantu, E., Sánchez, E.E., Pérez, J.C. (2009) cDNA cloning, expression and fibrin(ogen)olytic activity of two low-molecular weight snake venom metalloproteinases. Toxicon 54, 233-243.
  24. Barrios, M., Rodríguez-Acosta, A., Gil, A., Salazar, A.M., Taylor, P., Sánchez, E.E., Arocha-Piñango, C.L., Guerrero, B. (2009) Comparative hemostatic parameters in BALB/c, C57BL/6 and C3H/He mice. Thromb Res. 124, 338-343.
  25. Sánchez, E.E., Rodriguez-Acosta, A, Palomar, R., Lucena, S.E., Bashir, S., Soto, J.G., Pérez, J.C. (2009) Colombistatin: a disintegrin isolated from the venom of the South American snake (Bothrops colombiensis) that effectively inhibits platelet aggregation and SK-Mel-28 cell adhesion. Arch Toxicol. 83, 271-279.*
  26. Da Silva, M., Lucena, S., Aguilar, I., Rodríguez-Acosta, A., Salazar, A.M., Sánchez, E.E., Giron, M.E., Caravajal, Z., Arocha-Piñango, C.L., Guerrero, B. (2009) Anti-platelet effect of cumanastatin 1, a disintegrin isolated from venom of South American Crotalus rattlesnake. Thromb Res. 123, 731-739.
  27. Salazar, A.M., Guerrero, B., Cantu, B., Cantu, E., Rodríguez-Acosta, A., Perez, J.C., Galan, J.A., Tao, A., Sánchez, E.E. (2009) Venom variation in hemostasis of the southern Pacific rattlesnake (Crotalus oreganus helleri): Isolation of hellerase. Comp Biochem Physiol C Toxicol Pharmacol. 149, 273-277.*
  28. Pérez, J. C., Finberg, R., Sánchez, E. E. (2008). Important Considerations in Developing Antivenom. In: Hayes, W.K., Kent, R.B., Cardwell, M.D., Bush, S.P., (Eds.), The Biology of Rattlesnakes. Loma Linda University Press, Loma Linda, CA.
  29. Pineda, M.E., Giron, M.E., Estrella, A., Sánchez, E.E., Aguilar, I., Fernandez, I., Vargas, A.M., Scannone, H., Rodríguez-Acosta, A. (2008) Inhibition of the hemorrhagic and proteolytic activities of Lansberg's hognose pit viper (Porthidium lansbergii hutmanni) venom by opossum (Didelphis marsupialis) serum: isolation of Didelphis marsupialis 0.15Dm Fraction on DEAE-cellulose chromatography. Immunopharmacol Immunotoxicol. 30, 883-896
  30. Sánchez, E.E., Rodríguez-Acosta, A. (2008). Inhibitors of snake venoms and development of new therapeutics. Immunopharmacol Immunotoxicol. 30, 647-678.
  31. Salazar, A.M., Aguilar, I., Guerrero, B., Giron, M.E., Lucena, S., Sánchez, E.E., Rodríguez-Acosta, A. (2008) Intraspecies differences in hemostatic venom activities of the South American rattlesnakes, Crotalus durissus cumanensis, as revealed by a range of protease inhibitors. Blood Coagulation and Fibrinolysis. 19, 525-530.
  32. Pornmanee, P., Perez, J.C., Sánchez, E.E., Khow, O., Pakmanee, N., Chulasugandha, P., Chanhome, L., Petsom, A. (2008) pH gradient electrophoresis and biological activity analysis of proteins from Malayan pit viper (Calloselasma rhodostoma) venom. ScienceAsia 34, 273-277.
  33. Pornmanee, P., Sánchez, E.E., López, G., Petsom, A., Khow, O., Pakmanee, N., Chanhome, L., Sangvanich, P., Pérez, J.C. (2008) Neutralization of lethality and proteolytic activities of Maylayan pit viper (Calloselasma rhosdostoma) venom with North American Virginia Opossum (Didelphis virginiana) serum. Toxicon. 52, 186-189.
  34. Jia, Y., Cantu, B., Sánchez, E.E., Pérez, J.C. (2008) Complementary DNA sequencing and identification of mRNAs from venomous gland of Agkistrodon piscivorus leucostoma. Toxicon 51, 1457-1466.
  35. Galán, J.A., Sánchez, E.E., Rodríquez-Acosta, A., Soto, J.G., Bashir, S., McLane, M.A., Paquette-Straub, C., Pérez, J.C. (2008) Inhibition of lung tumor colonization and cell migration with the disintegrin crotatroxin 2 isolated from the venom of Crotalus atrox. Toxicon 51, 1186-1196.*
  36. Galán, J.A., Guo, M., Sánchez, E.E., Cantu, E., Rodríguez-Acosta, A., Pérez, J.C., Tao, W.A. (2008) Quantitative analysis of snake venoms using soluble polymer-based isotope labeling. Mol Cell Proteomics. 7, 785-799.
  37. Sánchez, E.E., Lopez-Johnston, J.C., Rodríguez-Acosta, A., Pérez, J.C. (2008) Neutralization of two North American coral snake venoms with United States and Mexican antivenoms. Toxicon. 51, 297-303.*
  38. Girón, M.E., Salazar, A.M., Aguilar, I., Pérez, J.C., Sánchez, E.E., Arocha-Piñango, C.L., Rodríguez-Acosta, A., Guerrero, B. (2007) Hemorrhagic, Coagulant and Fibrino(geno)lytic Activities of Crude Venom and Fractions from Mapanare (Bothrops colombiensis) snakes. Comp. Biochem. Phys. Part C. 147, 113-121.
  39. Aguilar, I., Guerrero, B., Salazar, A.M., Girón, M.E., Pérez, J.C., Sánchez, E.E., Rodriquez-Acosta, A. (2007) Rattlesnake Crotalus durissus cumanensis venom variability: coagulant, fibrino(geno)lytic, hemorrhagic and lethal activities. Toxicon. 50, 214-224.
  40. Rodríguez-Acosta, A., Magaldi, S., Pérez, J.C., Sánchez, E.E., Girón, M.E., Aguilar, I. (2007) A protein homology detection between rattlesnakes (Viperidae: Crotalinae) from South and North America deduced from antigenically related metalloproteases. Animal Biology 57, 401-407.
  41. Soto, J.G., White, S.A., Reyes, S.R., Regalado, R., Sánchez, E.E., Pérez, J.C. (2006) Molecular evolution of PIII-SVMP and RGD disintegrin genes from the genus Crotalus. Gene 389, 66-72.
  42. Soto J. G., Powell, R.L., Reyes, S.R., Wolana, L., Swanson, L.J., Sánchez, E.E., Pérez J. C. (2006) Genetic variation of a disintegrin gene found in the American copperhead snake (Agkistrodon contortrix). Gene 373, 1-7.
  43. Powell, R. L., Sánchez, E.E., Perez, J. C. (2006) Farming for venom: Survey of snake venom extraction facilities worldwide. Applied Herpetology 3, 1-10.
  44. Sánchez, E.E., Galán, J. A., Soto, J. G., Russell, W. K., Russell, D. H., Pérez, J. C. (2006) Isolation and Characterization of Two Disintegrins Inhibiting ADP-Induced Human Platelet Aggregation From The Venom of Crotalus scutulatus scutulatus (Mohave Rattlesnake). Toxicol. Appl. Pharmacol. 212, 59-68.
  45. Galán, J.A., Sánchez, E.E., Bashir, S., Pérez, J.C. (2005) Characterization and identification of disintegrins in Crotalus horridus venom by liquid chromatography and tandem matrix-assisted laser desorption ionization time-of-flight (QIT-MALDI-TOF) mass spectrometry. Can. J. Chem. 83, 1124-1131.
  46. Sánchez, E. E., Galán, J. A., Powell, R. L., Reyes, S. R., Soto, J. G., Russell, W. K., Russell, D. H., Pérez, J. C. (2005) Disintegrin, hemorrhagic, and proteolytic activities of Mohave rattlesnake, Crotalus scutulatus scutulatus venoms lacking Mojave toxin. J Comp. Biochem Physiol (Part C) 141, 124-132.
  47. Giron, M.E., Aguilar, I., Romero, L., Sánchez, E.E., Perez, J.C., Rodriguez-Acosta, A. (2005) A low-cost method to test cytotoxic effects of Crotalus vegrandis (serpents: viperidae) venom on kidney cell cultures. Rev Instituto de Medicina Tropical de Sao Paulo. 47, 147-152.
  48. Sánchez, E.E. (2004) Desintegrinas en veneno de serpientes: Un nuevo enfoque en el tratamiento de las enfermedades cardiovasculares, cancer-diábetes. Revista de la Facultad de Medicina, 27, 10-14.
  49. McLane, M.A., Sánchez, E.E., Wong, A., Paquette-Straub, C., Pérez, J.C. (2004) Disintegrins. Current Drug Target-Cardiovascular and Haemotological Disorders. 4, 327-355.
  50. Galán, J.A., Sánchez, E.E., Rodríguez-Acosta, A., Pérez, J.C. (2004) Neutralization of venoms from two Southern Pacific Rattlesnakes (Crotalus helleri) with commercial antivenoms and endothermic animal sera. Toxicon 43, 791-799.
  51. Caraballo, A., Navarro, J., Sánchez, E.E., Perez, J.C., Rodriguez-Acosta, A. (2004) Epidemiological and clinical aspects of snakebites in Bolivar State, Venezuela. Revista de la Facultad de Medicina 27, 25-28.
  52. Navarro, J., Caraballo, A., Sánchez, E., Pérez, J.C., Rodríguez-Acosta, A. (2003) Epidemiological and clinical aspects of snakebites in Monagas State, Venezuela. Revista de la Facultad de Medicina 26, 100-104.
  53. Sánchez, E.E., Galan, J.A., Perez, J.C., Rodriguez-Acosta, A., Chase, P.B., Perez, J.C. (2003) The efficacy of two antivenoms against the venom of North American snakes. Toxicon 41, 357-365.
  54. Sánchez, E.E., Ramirez, M.S., Galan, J.A., Lopez, G., Rodriguez-Acosta, A., Perez, J.C. (2003) Cross reactivity of three antivenoms against North American snake venoms. Toxicon 41, 315-320.
  55. Perez J. C., McKeller, M.R., Pérez, J. C., Sánchez, E. E., Ramirez, M.S. (2001) An internet database of crotaline venoms found in the United States. Toxicon 39, 621-632.
  56. Sánchez E.E., Soliz, L.A., Ramirez, M.S., Pérez, J.C. (2001) Partial characterization of a basic protein from Crotalus molossus molossus (northern blacktail rattlesnake) venom and production of a monoclonal antibody. Toxicon 39, 523-537.
  57. Martinez R.R., Pérez, J.C., Sánchez, E.E., Campos, R. (1999) The antihemorrhagic factor of the Mexican ground squirrel (Spermophilus mexicanus). Toxicon 37, 949-954.
  58. Ramirez, M.S., Sánchez, E.E., Garcia-Prieto, C., Perez, J.C., Rodriguez, G., McKeller, M.R., Ramirez, R., DeAnda, Y. (1999) Screening for fibrinolytic activity in eight Viperidae venoms. J Comp. Biochem Physiol 124, 91-98.
  59. Pérez, J. C., Sánchez, E. E., (1999) Natural protease inhibitors to hemorrhagins in snake venoms and their potential use in medicine. Toxicon 37, 703-728.
  60. Sánchez, E. E., Garcia, C., Pérez, J. C., De La Zerda, S. J. (1998) The detection of hemorrhagic proteins in snake venoms using monoclonal antibodies against Virginia opossum (Didelphis virginiana) serum. Toxicon 36, 1451-1459.


 Applications of Recombinant Snake Venom Derived Components in Hemostatic Disorders. Department of Arts and Sciences. $9,160. Role: P.I. 2011.

 “Evaluation of Instituto Bioclon Coralymn TM Coral Snake Antivenoms on Two North American Coral Snake Venoms” Laboratorio Silanes/Bioclon $15,000. Role: P.I. 2007

 “Evaluation of Wyeth North American Coral Snake Antivenom on Two North American Coral Snake Venoms” Wyeth Pharmaceutical $15, 000. Role: P.I. 2006

 5 P20 MD000216 Pérez, John C. (PI) 09/30/02 – 09/29/08 NIH/NCMHD/RIMI Texas A&M University-Kingsville Biomedical Research Program The major goals of this project are to   strengthen the University’s research programs and expand the research in the NTRC. The departments of Biology, Chemistry, Psychology/Sociology, Animal and Wildlife Sciences and the School of Pharmacy were selected to participate. The research goal in this project is to measure metalloproteinases inhibitors in serum opossum. Role: Co-PI Overlap: None

 #1 P40 RR018300 Pérez, John C. (PI) 4/01/03 – 03/31/08 NIH/NCRR Viper Resource Center at Texas A&M University-Kingsville The major goal of this project is to screen snake venoms for metalloproteinases and disintegrins that have potential in blocking tumor metastasis. Role: Co-PI Overlap: None

 #1 P40 RR018300-06 Pérez, John C. (PI) 4/01/08 – 03/31/13 NIH/NCRR Viper Resource Center at Texas A&M University-Kingsville The major goal of this project is to screen snake venoms for metalloproteinases and disintegrins that have potential in blocking tumor metastasis. Role: Co-PI Overlap: None

Contact Information

National Natural Toxins Research Center
975 W. Avenue B, Kleberg Hall Rm#100
MSC 158 Texas A&M University-Kingsville
Kingsville, Texas 78363-8202
voice: (361) 593-3082
email: elda.sanchez@tamuk.edu
Personal Website:

This page was last updated on: April 07, 2014