Associate Professor & NNTRC Director

Personnel Profile

Dr. Elda E. Sánchez, Associate Professor & NNTRC Director

Dr. Elda E. Sánchez

Education

 2004 - Ph.D., Toxinology, Universidad Central de Venezuela, Caracas, Venezuela

 1999 - M.S., Biology, Texas A&M University - Kingsville, Kingsville, Texas

 1993 - B.S., Biology, Texas A&I University, Kingsville, Texas


Experience

 Editorial Boards:

 -Revista de la Facultad de Medicina- Universidad Central de Venezuela, Caracas, Venezuela

 Employment:

-2017 - Present

Director, NNTRC

 Texas A&M University - Kingsville

 -2016 - Present

 Associate Professor, Department of Chemistry

 Texas A&M University - Kingsville

 -2013 - 2017

 Executive Co-Director, NNTRC

 Texas A&M University - Kingsville

 -2011 - 2012

 Interim Director, NNTRC

 Texas A&M University - Kingsville

 -2010 - Present

 Assistant Professor, Department of Chemistry

 Texas A&M University - Kingsville

 -2003 - 2011

 Assistant Director, NNTRC, TAMUK

 -1996 - 2003

 Laboratory Director, NTRC

 Texas A&M University - Kingsville

 -1994 - 1996   

 Graduate Research Assistant, NIH/MBRS Program

 Texas A&M University - Kingsville

 -1990 - 1993

 Undergraduate Research Assistant, NIH/MBRS Program

 Texas A&I University

 -1993 - B.S., Biology

 Cum Laude

 Texas A&I University -Kingsville

 Kingsville, Texas

Honors/Awards

- Minority Access, Inc., National Role Model Faculty Research Award (2014)

- Hall of Fame of Y Women In Careers (2012)

 -Minority Access, Inc., National Role Model Alumna Award (2005)

 -The Natural Toxins Research Center’s Commitment and Scientific Contribution Award (2005)

 -Graduated with honors (Summa Cum Laude, 2004, Ph.D.)

 -Women’s Center Bridging the GAP Award (March 1998)

 -NIH-AAMC-SACNAS Biomedical Research Poster Session Award (October 1997)

 -Biology Department Bogusch Memorial Scholarship recipient (1993)

 -Graduated with honors (Cum Laude, 1993, B.S.) •

 -National Hispanic Scholarship Fund recipient (1991, 92, 93)

 -Ed Rachel Scholarship recipient (4 yrs)

Invited Presentations

  1. Audubon Outdoor Club of Corpus Christi. The National Natural Toxins Research Center: An Overview. South Texas Botanical Garden, Corpus Christi, TX. Nov. 8, 2016.
  2. Texas Rattlesnake Festival. Current research in venoms in the treatment of diseases and envenomations. Lone Star Convention Center, Conroe, TX. March 12-13, 2016.
  3. Keynote Speaker: Venom Week V. Neutralization of crotamine isoforms with a chemically-modified DNA aptamer: Development of a synthetic antivenom. East Carolina University, Greenville, NC. March 9-12, 2016.
  4. Texas A&M University-Kingsville President’s Leadership Council. National Natural Toxins Research Center at Texas A&M University-Kingsville. Marriott Plaza San Antonio. San Antonio, TX. Dec. 3, 2015.
  5. 18th World Congress of the International Society on Toxinology. Neutralization of Snake Venom Myotoxins with a DNA-Modified Aptamer: An Approach to the Development of Universal Antivenom. University of Oxford, Oxford, UK. Sept. 25-30, 2015.
  6. The TAMIU GREAT Program. The Venom Gland cDNA Library of the Southern Pacific Rattlesnake (Crotalus oreganus helleri): The Quest for Novel Therapeutic Molecules. Texas A&M International University. Laredo, TX, April 11, 2014.
  7. College of Pharmacy Colloquium. “The venom-gland, cDNA library of the Southern Pacific Rattlesnake: A valuable tool for identifying new therapeutics and targeting agents for various cell types.” Irma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, TX, June 27-28, 2013.
  8. Industry Day. “The National Natural Toxins Research Center.” Texas A&M University-Corpus Christi, Corpus Christi, TX. June 12, 2013.
  9. NIH Grand Writing Workshop, Lexington, KY, May 6-8, 2013
  10. AVID Summer Institute, Dallas, TX, June 24-27, 2012.
  11. Keynote speaker at the Falfurrias High School Graduation. Falfurrias, TX, June 2, 2012.
  12. Kingsville Rotary Club. The Inhibition Processes Involved In Cancer Progression by Snake Venom Molecules.” Kingsville, TX, Jan. 10, 2012.
  13. Presentation for the Chancellor of the Texas A&M System. “The Inhibition Processes Involved In Cancer Progression by Snake Venom Molecules.” Texas A&M University-Kingsville. June 14, 2011.
  14. The University of the Future-5th Conference on the Scholarship of Teaching and Learning, Winds of Change. “Success with Undergraduate Researchers is Possible.” Texas A&M University-Kingsville, Kingsville, TX, Feb. 10-11, 2011.
  15. American Chemical Society local meeting, Texas A&M University-Kingsville, Kingsville, TX, Nov. 19, 2010. “Preventing blood coagulation with a venom molecule (disintegrin) of the Mohave rattlesnake.”
  16. Coordinator for the North American Session of Antivenoms. 9th International Meeting of Experts in Venomous Animal Poisoning. Cuernavaca, Mexico. Oct. 18-21, 2010.
  17. Society of Forensics Toxicology meeting, Oklahoma City, OK, Oct. 19, 2009. “Toxicity and Biochemistry of Venoms from Snakes of North America.”
  18. North American Congress of Clinical Toxicology (NACCT) meeting, San Antonio, TX, Sept. 25, 2009. “Antivenoms”
  19. Venom Week, Albuquerque, NM, June 1-5, 2009. “The Recombinant Disintegrin of the Mohave Rattlesnake”
  20. Exogenous Factors Affecting Thrombosis and Hemostasis, Boston, MS, July 17-19, 2009. “The Battle of Neutralizing and Treating Snakebites in the 21st Century: Have We Made Progress?”
  21. Taller Internacional Sobre Toxinas De Animales Venenosos, Universidad De Los Andes, Merida, Venezuela, Jan. 17 & 18, 2008. “Desintegrinas En Veneno De Serpientes: Una Revisión.” And “Estudio De La Variación Intraespecie En El Veneno De Serpientes De La Familia Viperidae, Como Un Aporte Para El Diseño De Sueros Antiofídicos.”
  22. Venom Week, Tucson, AZ, Sept. 3-7, 2007. “Hemorrhagic, Fibrino(geno)lytic, Coagulant and Lethal Activities of Venom from the Southern Pacific Rattlesnakes, Crotalus oreganus helleri.”
  23. Universidad Central de Venezuela. Caracas, Venezuela, June 15, 2007. “Desintegrinas En Veneno De Serpientes: Una Revisión.”
  24. Texas A&M University Health Science Center, Institute of Biosciences and Technology, Houston, TX, Nov. 9, 2005. “Snake Venom Disintegrins: Their Role in Biomedical Research.”
  25. Seminar speaker at San Jose State University, San Jose, CA, Oct. 26, 2005. “Snake Venom Biomedical Research at the Natural Toxins Research Center.”
  26. Snakebites in the New Millennium: A State-of-the-Art Symposium, Omaha, Nebraska, Oct. 23, 2005. “Inhibition of Two North American Coral Snake Venoms by the United States and Mexican Coral Snake Antivenoms.”
  27. 7ta Reunion de Expertos en Envenenamiento por Animales Ponzoñosos, Cuernavaca, Morelos, Mexico, March 2005. “Neutralization of Two U.S. Coral Snake Venoms: A Comparative Study.
  28. Biology of the Rattlesnakes Symposium, Loma Linda , California, Jan. 15-18, 2005. “Isolation of two disintegrins from Crotalus scutulatus scutulatus (Mojave Rattlesnake) venom lacking Mojave toxin.” and “ Important considerations of developing antivenom.”
  29. Border Health Lecture Series, Brownsville, Texas, Dec. 10, 2004. “Isolation of two disintegrins from Crotalus scutulatus scutulatus (Mojave Rattlesnake) venom lacking Mojave toxin.” and “ Important considerations of developing antivenom.”
  1. 2nd Interamerican Workshop on Natural Toxins. Universidad Central de Venezuela, Caracas, Venezuela, Dec. 2004. “Actividad de desintegrinas en veneno de serpientes Norteamericanas y Venezolanas.”
  2. 6ta Reunion de Expertos en Envenenamiento por Animales Ponzoñosos, Cuernavaca, Morelos , Mexico, March 2003. “Utilización del Sonoclot y Agregometro de Plaquetas para Determinar la Eficacia de los Antivenenos.”
  3. “Taller Internacional”- Instituto Bioclón, Mexico City, Mexico. Metodos de equivalencia de antivenenos contra la picadura de alacran y morderura por serpiente (Bothrops). 2002. “Methods for determining the efficacy of antivenoms vs. venom of North American pit vipers.”
  4. North American Congress of Clinical Toxicology. Palm Springs, CA. 2002. “Efficacy of two antivenoms vs. venom of North American pit vipers.”
  1. 6th PanAmerican Congress on Animal, Plant and Microbial Toxins. 1998. Margarita Island, Venezuela. “Comparison of Viperidae Venoms by High Performance Liquid Chromatography and Proteolytic Assays.”
  2. 7th Symposium of the Pan American Section. The International Society of Toxinology of Plant, Animal and Bacterial Toxins. University of Virginia, Charlottesville, VA. 2001. “Quick method of measuring the effects of snake venom on the human clotting cascade and neutralization of the venom.”
  3. International Conference on Exogenous Factors Affecting Thrombosis and Haemostasis.  Institute Pasteur, Paris, France. 2001. “Quick method of measuring the effects of snake venom on the human clotting cascade and neutralization of the venom.”
  1. 1st  InterAmerican Workshop on Natural Toxins. Universidad Central de Venezuela, Caracas, Venezuela. July, 2000. “Detection of proteolytic proteins in snake venom by five step western blot using monoclonal antibodies.”

Publications

  1. Nielsen, V.G., Sánchez, E.E., Redford, D.T. (2017) Characterization of the rabbit as an in vitro and in vivo model to assess the effects of fibrinogenolytic activity of snake venom on coagulation. Basic Clin Pharmacol Toxicol. (Epub ahead of print).

  2. Schield, D.R., Adams, R.H., Card, D.C., Perry, B.W. Pasquesi, G.M., Jezkova, T., Portik, D.M., Andrew, A.L., Spencer, C.L., Sanchez, E. E., Fujita, M.K., Mackessy, S.P., Castoe, T.A. (2017) Insight into the roles of selection in speciation from genomic patterns of divergence and introgression in secondary contact in venomous rattlesnakes. Ecol Evol. 7; 3951-3966.

  3. Rokyta, D.R., Margres, M.J., Ward, M.J. Sánchez, E.E. (2017) The genetics of venom ontogeny in the eastern diamondback rattlesnake (Crotalus adamanteus). PeerJ. (eCollection)

  4. Zhang, Chuchu, Medzihradszky, K.F., Sánchez, E.E., Basbaum, A.I., Julius, D. (2017) Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release. Proc Natl Acad Sci USA. 114: E2524-E2532.

  5. Cantu, E, Jr., Mallela, S., Nyguen, M., Báez, R., Parra, V., Johnson, R., Wilson, K., Suntravat, M., Lucena, S. Rodriguez-Acosta, A., Sánchez, E.E. (2017) The binding effectiveness of anti-disintegrin polyclonal antibodies against disintegrins and PII and PIII metalloproteases: An immunological survey of type A, B and A+B venoms from Mohave rattlesnakes. Comp. Biochem. Physiol C Toxicol Pharmacol. 191, 168-176.

  6. Komives, C.F., Sanchez, E.E., Rathore, A.S., White, B., Suntravat, M., Balderrama, M., Cifelli, A., Joshi, V. (2017) Opossum peptide that can neutralize rattlesnake venom is expressed in Escherichia coli. Biotechnol Prog. 33, 81-86.

  7. Gutierrez, D.A., Aranda, A.S., Carrillo, D.A., Koshlaychuk, M.A., Sanchez, E.E., Lucena, S.E., Soto, J.G. (2016) Functional analysis of four single (RGDWL, RGDWM, RGDWP, RGDMN)        and two double (RGDNM, RGDMP) mutants: The importance of methionine (M) in the functional potency of recombinant mojastin (r-Moj). Toxicon 124, 1-7.

  8. Suntravat, M., Helmke, T.J., Atphaisit, C., Cuevas, E., Lucena, S.E., Uzcátegui, N.L. Sanchez, E.E.*, Rodriguez-Acosta. (2016) Expression, purification, and analysis of three recombinant ECD disintegrins (r-colombistatins) from P-III class snake venom metalloproteinases affecting platelet aggregation and SK-MEL-28 cell adhesion. Toxicon 122, 43-49. *Corresponding Author.

  9. Dowell, N.L., Giorgianni, M.W., Kassner, V.A., Selegue, J.E., Sanchez, E.E., Carroll, S.B. (2016) The deep origin and recent loss of venom toxin genes in rattlesnakes. Curr Biol.26, 2434-45.

  10. Marges, M. Walls, R.I., Suntravat, M., Lucena, S., Sanchez, E.E., Rokyta, D. (2016) Functional characterizations of venom phenotypes in the Eastern diamondback rattlesnake (Crotalus adamanteus) and evidence for expression-driven divergence in toxic activities among populations. Toxicon 119, 28-38.

  11. Ramos, C.J., Gutierrez, D.A., Aranda, A.S., Koshlaychuk, M.A., Carrillo, D.A., Medrano, R., McBride, T.D. U, A., Medina, S.M., Lombardo, M.C., Lucena, S.E., Sanchez, E.E., Soto, J.G. (2016) Functional characterization of six aspartate (D) recombinant mojastin mutants (r-Moj): A second aspartate amino acid carboxyl to the RGD in r-Moj-D_peptides is not sufficient to induce apoptosis of SK-Mel-28 cells. Toxicon 118, 36-42.

  12. Sánchez, E.E., Rodriguez-Acosta, A. (2016) Comparative analysis of biological and biochemical venom characteristics of North and South American Crotalus (Serpentes: Viperidae) snake species: An introductory approximation to understand their biological functions. Saber, Universidad de Oriente, Venezuela 28, 40-61.
  13. Borja, M., Galan, J.A., Cantu, E., Zugasti-Cruz, A., Rodriguez-Acosta, A., Lazcano, D., Lucena, S., Suntravat, M., Sánchez, E.E. (2016) Morulustatin, a disintegrin that inhibits ADP-induced platelet aggregation, isolated from the Mexican Tamaulipan rock rattlesnake (Crotalus lepidus morulus). Revista Cientifica, FCV-LUZ. XXVI, 86-94.
  14. Rodriguez-Acosta, A., Lucena, S., Alfonso, A., Goins, A., Walls, R., Guerrero, B., Suntravat, M., Sánchez, E. E. (2016) Biological and biochemical characterization of venom from the broad-banded copperhead (Agkistrodon contortrix laticinctus): isolation of two new dimeric disintegrins. Animal Biology 66, 173-187.
  15. Lucena, S., Rodriguez-Acosta, A., Grilli, E., Alfonso, A., Goins, A., Ogbata, I., Walls, R., Suntravat, M., Uzcategui, N.L., Guerrero, B., Sánchez, E.E. (2016) The characterization of trans-pecos copperhead (Agkistrodon contortrix pictigaster) venom and isolation of two new dimeric disintegrins. Biologicals 44, 191-197.
  16. Suntravat, M., Uzcategui, N.L., Atphaisit, C., Helmke, T.J., Lucena, S.E., Sánchez, E.E.*, Rodriguez-Acosta, A.R. (2016) Gene expression profiling of the venom gland from the Venezuelan mapanare (Bothrops colombiensis) using expressed sequence tags (ESTs). BMC Mol Biol. 17, 7. *Corresponding Author.
  17. Vivas, J., Ibarra, C., Salazar, A.M., Neves-Ferreira, A.G., Sánchez, E.E., Perales, J., Rodriguez-Acosta, A., Guerrero, B. (2016) Purification and characterization of tenerplasminin-1, a serine peptidase inhibitor with antiplasmin activity from the coral snake (Micrurus tener tener) venom. Comp Biochem Physiol C Toxicol Pharmacol 179, 107-115.
  18. Suntravat, M., Barret, H.S., Jurica, C.A., Lucena, S.E., Perez, J.C., Sánchez, E.E. (2015) Recombinant disintegrin (r-Cam-dis) from Crotalus adamanteus inhibits adhesion of human pancreatic cancer cell lines to laminin-1 and vitronectin. J Venom Res 6, 1-10.
  19. Lucena, S.E., Castro, R., Lundin, C., Hofstetter, A., Alaniz, A.,Suntravat, M., Sánchez, E.E. (2015) Inhibition of pancreatic tumoral cells by snake venom disintegrins. Toxicon 93, 136-143.
  20. Lomonte, B., Tsai, W.C., Ureña-Diaz, J.M., Sanz, L., Mora-Obando, D., Sánchez, E.E., Fry, B.G., Gutiérrez, J.M., Gibbs, H.L., Sovic, M.G., Calvete, J.J. (2014) Venomics of New World pit vipers: genus-wide comparisons of venom proteomes across Agkistrodon. J Proteomics 96, 103-116.
  21. Lucena, S.E., Romo, K. Suntravat, M., Sánchez, E.E. (2014) Anti-angiogenic activities of two recombinant disintegrins derived from the Mohave and Prairie rattlesnakes. Toxicon 78, 10-17.Sánchez, E.E., Girón, M.E., Uzcátegui, N.L., Guerrero, B., Saucedo, M., Cuevas, E., Rodríguez-Acosta, A. (2014) Biochemical and biological characterization of lancehead (Bothrops venezuelensis Sander 1952) snake venom from the Venezuelan Central Coastal range. Boletín De Malariología y Salud Ambiental LIV, 138-149.
  22.  Aguilar, I., Sánchez, E.E., Girón, M.E., Estrella, A., Guerrero, B., Rodriguez-Acosta, F.A. (2014) Coral snake antivenom produced in chickens (Gallus domesticus). Rev Inst Med Trop Sao Paulo. 56, 61-66.
  23. Borja M, Lazcano D, Martínez-Romero G, Morlett J, Sánchez E, Cepeda-Nieto AC, Garza-Garcia Y, Zugasti-Cruz A. (2013) Intra-specific Variation in the Protein Composition and Proteolytic Activity of Venom of Crotalus lepidus morulus from the Northeast of Mexico. Copeia. 4, 707-716.
  24. Suntravat, M., Jia, Y., Lucena, S.E., Sánchez, E.E., Perez, J.C. (2013). cDNA cloning of a snake venom metalloproteinase from the eastern diamondback rattlesnake (Crotalus adamanteus), and the expression of its disintegrins domain with anti-platelet effects. Toxicon 64, 43-54.
  25. Girón, M.E., Rodríguez-Acosta, A., Salazar, A.M., Sánchez, E.E., Galán, J., Ibarra, C., Guerrero, B. (2013). Isolation and characterization of two new non-hemorrhagic metalloproteinases with fibrinolytic activity from the mapanare (Bothrops colombiensis) venom. Arch Toxicol. 1, 197-208.
  26. Lucena, S.E., Jia, Y., Soto, J.G., Parral, J., Cantu, E., Brannon, J., Lardner, K., Ramos, C.J., Seoane, A.I., Sánchez, E.E.* (2012) Anti-invasive and anti-adhesive activities of recombinant disintegrin, r-viridistatin 2, derived from the Prairie rattlesnake (Crotalus viridis viridis). Toxicon 60, 31-39.
  27. Massey, D.J., Calvete, J.J., Sánchez, E.E.*, Sanz, L, Richards, K., Curtis, R., Boesen, K. (2012) Venom variability and envenoming severity outcomes of the Crotalus scutulatus scutulatus (Mojave rattlesnake) from Southern Arizona. J Proteomics 75, 2576-2587.*Corresponding Author
  28. Barrios, M., Taylor, P., Rodríguez-Acosta, A., Sánchez, E.E., Arocha-Pinango, C.L., Gil, A., Salazar A.M., Carvajal, Z., Abad, M.J., Guerrero, B. (2012) A mouse model to study the alterations in haemostatic inflammatory parameters induced by Lonomia achelous caterpillar haemolymph. Toxicon 59, 547-554.
  29. Calvete, J.J., Pérez, A., Lomonte, B., Sánchez, E.E., Sanz L. (2012) Snake venomics of Crotalus tigris: The minimalist toxin arsenal of the deadliest neartic rattlesnake venom. Evolutionary clues for generating a Pan-specific antivenom against Crotalid type II venoms. J Proteome Res. 11, 1382-1390.
  30. Carey, C.M., Bueno, R., Gutierrez, D.A., Petro, C., Lucena, S.E., Sánchez, E.E., Soto, J.G. (2012) Recombinant rubistatin (r-Rub), an MVD disintegrin, inhibits cell migration and proliferation, and is a strong apoptotic inducer of the human melanoma cell line SK-Mel-28. Toxicon 59, 241-248.
  31. Khunsap, S., Pakmanee, N., Khow, O., Chanhome, L., Sitprija, V., Suntravat, M., Lucena, S.E., Perez, J.C., Sánchez, E.E.* (2011) Purification of a phospholipase A2 from Daboia russelii siamensis venom with anticancer effects. J Venom Res. 2, 42-51.*
  32. Bohlen, C.J., Chesler, A.T., Sharif-Naeini, R., Medzihradszky, K.F., Zhou, S., King, D., Sánchez, E.E., Burlingame, A.L., Allan I. Basbaum, A.I., Julius, D. (2011) A Heteromeric toxin from Texas coral snake targets acid-sensing ion channels to produce pain. Nature. 479, 410-414.
  33. Sánchez, E.E.*, Hotle, D., Rodríguez-Acosta, A. (2011) Neutralization of Bitis parviocula (Ethiopian Mountain Adder) Venom by the South African Institute of Medical Research (SAIMR) Antivenom. Revista do Instituto de Medicina Tropical de São Paulo 53, 213-217.
  34. Guerrero, B., Arocha-Piñango, C.L., Salazar, A.M., Gil, A., Sánchez, E.E., Rodríguez-Acosta, A., Lucena, S. (2011) The effects of Lonomin V, a toxin from the caterpillar (Lonomia achelous), on hemostasis parameters as measured by platelet function. Toxicon 58, 293-303.
  35. Salazar, A.M., Vivas, J., Sánchez, E.E., Rodríguez-Acosta, A., Ibarra, C., Gil, A., Carvajal, Z., María E. Girón, M.E., Estrella, A., Navarrete, L.F., Guerrero, B. (2011) Hemostatic and toxicological diversities in venom of  Micrurus tener tener, Micrurus fulvius fulvius and Micrurus isozonus coral snakes. Toxicon 58, 35-45.
  36. Lucena, S., Sanchez, E.E., Perez, J.C. (2011) Anti-metastatic Activity of the Recombinant Disintegrin, r-Mojastin 1, from the Mohave Rattlesnake. Toxicon 57, 794-802.
  37. Teklemariam, T., Seoane, A.I., Ramos, C.J., Sanchez, E.E., Lucena, S.E., Perez, J.C., Mandal, S.A., Soto, J.G. (2011) Functional analysis of a recombinant PIII-SVMP, GST-acocostatin; an apoptotic inducer of HUVEC and HeLa, but not SK-Mel-28 cells. Toxicon 57, 646-656.
  38. Girón, M.E., Estrella, A., Sánchez, E.E., Galán, J., Tao, W.A., Guerrero, B., Salazar, A.M., Rodríguez-Acosta, A. (2011) Purification and characterization of a metalloproteinase, Porthidin-1, from the venom of Lansberg's hog-nosed pitvipers (Porthidium lansbergii hutmanni). Toxicon 57, 608-618.
  39. Estrella, A.†, Sánchez, E.E.†, Galán, J.A., Tao, W.A., Guerrero, B., Navarrete, L.F., Rodríguez-Acosta, A. (2011) Characterization of toxins from the broad-banded water snake Helicops angulatus (Linnaeus, 1758): isolation of a cysteine-rich secretory protein. Arch Toxicol. 85, 305-313. Authors contributed equally.
  40. Reyes-Lugo, M., Reyes-Contreras, M., Salvi, I., Gelves, W., Avilán, A., Llavaneras, D., Navarrete, L.F., Cordero, G., Sánchez, E.E., Rodríguez-Acosta A. (2011). The association of Triatoma maculata (Ericsson 1848) with the gecko Thecadactylus rapicauda (Houttuyn 1782) (Reptilia: Squmata: Gekkonidae): A strategy of domiciliation of the Chagas disease peridomestic vector in Venezuela? Asian Pacific J Trop Biomed 279-284.
  41. Rodriguez-Acosta, A., Sánchez, E.E., Marquez, A., Salazar, A.M., Giron, M.E., Caravajal, Z., Gil, A., Guerrero, B.  (2010) Hemostatic properties of Venenzuelan Bothrops snake venoms with special references to Bothrops isabelae venom. Toxicon 56, 926-935. Authors contributed equally.
  42. Sánchez, E.E., Lucena, S.E., Reyes, S., Soto, J.G., Cantu, E., Lopez-Johnston, J.C., Guerrero, B., Salazar, A.M., Rodríguez-Acosta, A., Galán, J.A., Tao, W.A., Pérez, J.C. (2010).  Cloning, expression, and hemostatic activities of a disintegrin, r-mojastin 1, from the Mohave rattlesnake (Crotalus scutulatus scutulatus). Thrombosis Research 126, e211-e219.
  43. Seoane, A.I., Tran, V.L., Sanchez, E.E., White, S.A., Choi. J.L., Gaytán, B., Chavez, N., Reyes, S.R., Ramos, C.J., Tran, L.H., Lucena, S.E., Sugarek, M., Perez, J.C., Mandal, S.A., Ghorab, S, Rodriguez-Acosta, A., Fung, B.K., Soto, J.G. (2010) The mojastin mutant Moj-DM induces apoptosis of the human melanoma SK-Mel-28, but not the mutant Moj-NN nor the non-mutated recombinant Moj-WN. Toxicon 56, 391-401.
  44. Gracheva, E.O., Ingolia, N.T., Kelly, Y.M., Cordero-Morales, J.F., Hollopeter, G., Chesler, A.T., Sánchez, E.E., Perez, J.C., Weissman, J.S., Julius, D. (2010) Molecular basis of infrared detection by snakes. Nature 464, 1006-1011.
  45. Guerrero, B., Finol, H.J., Reyes-Lugo, M., Salazar, A.M., Sánchez, E.E., Estrella, A., Roschman-González, A., Ibarra, C., Salvi, I., Rodríguez-Acosta, A. (2010) Activities against hemostatic proteins and adrenal gland ultrastructural changes caused by the brown widow spider  Latrodectus geometricus (Araneaea: Theridiide) venom. Comp Biochem Physiol, C Toxicol Pharmacol. 151, 113-121.
  46. Rodriguez-Acosta, A., Sánchez, E.E., Navarrete, L.F. (2010) Intensa reacción alérgica en paciente mordido por la hormiga negra (Odontomachus bauri). Rev Cubana Med Trop 62, 77-80.
  47. Reyes-Lugo, M., Sánchez, T., Finol, H.J., Sánchez, E.E., Suárez, J.A., Guerrero, B., Rodríguez-Acosta, A.  (2009) Neurotoxic activity and ultrastructural changes in muscles caused by the brown widow spider Latrodectus geometricus Koch, 1841 (Araneae: Theridiidae) venom. Revista do Instituto de Medicina Tropical de São Paulo  Rev. Inst. Med. Trop. S. Paulo. 51, 95-101.
  48. Jia, Y., Lucena, S., Cantu, E., Sánchez, E.E., Pérez, J.C. (2009) cDNA cloning, expression and fibrin(ogen)olytic activity of two low-molecular weight snake venom metalloproteinases. Toxicon 54, 233-243.
  49. Barrios, M., Rodríguez-Acosta, A., Gil, A., Salazar, A.M., Taylor, P., Sánchez, E.E., Arocha-Piñango, C.L., Guerrero, B. (2009) Comparative hemostatic parameters in BALB/c, C57BL/6 and C3H/He mice. Thromb Res. 124, 338-343.
  50. Sánchez, E.E., Rodriguez-Acosta, A, Palomar, R., Lucena, S.E., Bashir, S., Soto, J.G., Pérez, J.C. (2009) Colombistatin: a disintegrin isolated from the venom of the South American snake (Bothrops colombiensis) that effectively inhibits platelet aggregation and SK-Mel-28 cell adhesion. Arch Toxicol. 83, 271-279.*
  51. Da Silva, M., Lucena, S., Aguilar, I., Rodríguez-Acosta, A., Salazar, A.M., Sánchez, E.E., Giron, M.E., Caravajal, Z., Arocha-Piñango, C.L., Guerrero, B. (2009) Anti-platelet effect of cumanastatin 1, a disintegrin isolated from venom of South American Crotalus rattlesnake. Thromb Res. 123, 731-739.
  52. Salazar, A.M., Guerrero, B., Cantu, B., Cantu, E., Rodríguez-Acosta, A., Perez, J.C., Galan, J.A., Tao, A., Sánchez, E.E. (2009) Venom variation in hemostasis of the southern Pacific rattlesnake (Crotalus oreganus helleri): Isolation of hellerase.  Comp Biochem Physiol C Toxicol Pharmacol. 149, 273-277.*
  53. Pineda, M.E., Giron, M.E., Estrella, A., Sánchez, E.E., Aguilar, I., Fernandez, I., Vargas, A.M., Scannone, H., Rodríguez-Acosta, A. (2008) Inhibition of the hemorrhagic and proteolytic activities of Lansberg's hognose pit viper (Porthidium lansbergii hutmanni) venom by opossum (Didelphis marsupialis) serum: isolation of Didelphis marsupialis 0.15Dm Fraction on DEAE-cellulose chromatography. Immunopharmacol Immunotoxicol. 30, 883-896
  54. Sánchez, E.E., Rodríguez-Acosta, A. (2008). Inhibitors of snake venoms and development of new therapeutics. Immunopharmacol Immunotoxicol. 30, 647-678.
  55. Salazar, A.M., Aguilar, I., Guerrero, B., Giron, M.E., Lucena, S., Sánchez, E.E., Rodríguez-Acosta, A. (2008) Intraspecies differences in hemostatic venom activities of the South American rattlesnakes, Crotalus durissus cumanensis, as revealed by a range of protease inhibitors. Blood Coagulation and Fibrinolysis. 19, 525-530.
  56. Pornmanee, P., Perez, J.C., Sánchez, E.E., Khow, O., Pakmanee, N., Chulasugandha, P., Chanhome, L., Petsom, A. (2008) pH gradient electrophoresis and biological activity analysis of proteins from Malayan pit viper (Calloselasma rhodostoma) venom. ScienceAsia 34, 273-277.
  57. Pornmanee, P., Sánchez, E.E., López, G., Petsom, A., Khow, O., Pakmanee, N., Chanhome, L., Sangvanich, P., Pérez, J.C. (2008) Neutralization of lethality and proteolytic activities of Maylayan pit viper (Calloselasma rhosdostoma) venom with North American Virginia Opossum (Didelphis virginiana) serum. Toxicon. 52, 186-189.
  58. Jia, Y., Cantu, B., Sánchez, E.E., Pérez, J.C. (2008) Complementary DNA sequencing and identification of mRNAs from venomous gland of Agkistrodon piscivorus leucostoma. Toxicon 51, 1457-1466.
  59. Galán, J.A., Sánchez, E.E., Rodríquez-Acosta, A., Soto, J.G., Bashir, S., McLane, M.A., Paquette-Straub, C., Pérez, J.C. (2008) Inhibition of lung tumor colonization and cell migration with the disintegrin crotatroxin 2 isolated from the venom of Crotalus atrox. Toxicon 51, 1186-1196.*
  60. Galán, J.A., Guo, M., Sánchez, E.E., Cantu, E., Rodríguez-Acosta, A., Pérez, J.C., Tao, W.A. (2008) Quantitative analysis of snake venoms using soluble polymer-based isotope labeling. Mol Cell Proteomics. 7, 785-799.
  61. Sánchez, E.E., Lopez-Johnston, J.C., Rodríguez-Acosta, A., Pérez, J.C. (2008) Neutralization of two North American coral snake venoms with United States and Mexican antivenoms. Toxicon. 51, 297-303.*
  62. Girón, M.E., Salazar, A.M., Aguilar, I., Pérez, J.C., Sánchez, E.E., Arocha-Piñango, C.L., Rodríguez-Acosta, A., Guerrero, B. (2007) Hemorrhagic, Coagulant and Fibrino(geno)lytic Activities of Crude Venom and Fractions from Mapanare (Bothrops colombiensis) snakes. Comp. Biochem. Phys. Part C. 147, 113-121.
  63. Aguilar, I., Guerrero, B., Salazar, A.M., Girón, M.E., Pérez, J.C., Sánchez, E.E., Rodriquez-Acosta, A. (2007) Rattlesnake Crotalus durissus cumanensis venom variability: coagulant, fibrino(geno)lytic, hemorrhagic and lethal activities.  Toxicon. 50, 214-224.
  64. Rodríguez-Acosta, A., Magaldi, S., Pérez, J.C., Sánchez, E.E., Girón, M.E., Aguilar, I. (2007) A protein homology detection between rattlesnakes (Viperidae: Crotalinae) from South and North America deduced from antigenically related metalloproteases. Animal Biology 57, 401-407.
  65. Soto, J.G., White, S.A., Reyes, S.R., Regalado, R., Sánchez, E.E., Pérez, J.C. (2006) Molecular evolution of PIII-SVMP and RGD disintegrin genes from the genus Crotalus. Gene 389, 66-72.
  66. Soto J. G., Powell, R.L., Reyes, S.R., Wolana, L., Swanson, L.J., Sánchez, E.E., Pérez J. C. (2006) Genetic variation of a disintegrin gene found in the American copperhead snake (Agkistrodon contortrix). Gene 373, 1-7.
  67. Powell, R. L., Sánchez, E.E., Perez, J. C. (2006) Farming for venom: Survey of snake venom extraction facilities worldwide. Applied Herpetology 3, 1-10.
  68. Sánchez, E.E., Galán, J. A., Soto, J. G., Russell, W. K., Russell, D. H., Pérez, J. C. (2006) Isolation and Characterization of Two Disintegrins Inhibiting ADP-Induced Human Platelet Aggregation From The Venom of Crotalus scutulatus scutulatus (Mohave Rattlesnake). Toxicol. Appl. Pharmacol. 212, 59-68.
  69. Galán, J.A., Sánchez, E.E., Bashir, S., Pérez, J.C. (2005) Characterization and identification of disintegrins in Crotalus horridus venom by liquid chromatography and tandem matrix-assisted laser desorption ionization time-of-flight (QIT-MALDI-TOF) mass spectrometry. Can. J. Chem. 83, 1124-1131.
  70. Sánchez, E. E., Galán, J. A., Powell, R. L., Reyes, S. R., Soto, J. G., Russell, W. K., Russell, D. H., Pérez, J. C. (2005) Disintegrin, hemorrhagic, and proteolytic activities of Mohave rattlesnake, Crotalus scutulatus scutulatus venoms lacking Mojave toxin. J Comp.  Biochem Physiol (Part C) 141, 124-132.
  71. Giron, M.E., Aguilar, I., Romero, L., Sánchez, E.E., Perez, J.C., Rodriguez-Acosta, A. (2005) A low-cost method to test cytotoxic effects of Crotalus vegrandis (serpents: viperidae) venom on kidney cell cultures. Rev Instituto de Medicina Tropical de Sao Paulo. 47, 147-152.
  72. Sánchez, E.E. (2004) Desintegrinas en veneno de serpientes: Un nuevo enfoque en el tratamiento de las enfermedades cardiovasculares, cancer-diábetes. Revista de la Facultad de Medicina, 27, 10-14.
  73. McLane, M.A., Sánchez, E.E., Wong, A., Paquette-Straub, C., Pérez, J.C. (2004) Disintegrins. Current Drug Target-Cardiovascular and Haemotological Disorders. 4, 327-355.
  74. Galán, J.A., Sánchez, E.E., Rodríguez-Acosta, A., Pérez, J.C. (2004) Neutralization of venoms from two Southern Pacific Rattlesnakes (Crotalus helleri) with commercial antivenoms and endothermic animal sera. Toxicon 43, 791-799.
  75. Caraballo, A., Navarro, J., Sánchez, E.E., Perez, J.C., Rodriguez-Acosta, A. (2004) Epidemiological and clinical aspects of snakebites in Bolivar State, Venezuela. Revista de la Facultad de Medicina 27, 25-28.
  76. Navarro, J., Caraballo, A., Sánchez, E., Pérez, J.C., Rodríguez-Acosta, A. (2003) Epidemiological and clinical aspects of snakebites in Monagas State, Venezuela. Revista de la Facultad de Medicina 26, 100-104
  77. Sánchez, E.E., Galan, J.A., Perez, J.C., Rodriguez-Acosta, A., Chase, P.B., Perez, J.C. (2003) The efficacy of two antivenoms against the venom of North American snakes. Toxicon 41, 357-365.
  78. Sánchez, E.E., Ramirez, M.S., Galan, J.A., Lopez, G., Rodriguez-Acosta, A., Perez, J.C. (2003) Cross reactivity of three antivenoms against North American snake venoms. Toxicon 41, 315-320.
  79. Perez J. C., McKeller, M.R., Pérez, J. C., Sánchez, E. E., Ramirez, M.S. (2001) An internet database of crotaline venoms found in the United States.  Toxicon 39, 621-632.
  80. Sánchez E.E., Soliz, L.A., Ramirez, M.S., Pérez, J.C. (2001) Partial characterization of a basic protein from Crotalus molossus molossus (northern blacktail rattlesnake) venom and production of a monoclonal antibody. Toxicon 39, 523-537.
  81. Martinez R.R., Pérez, J.C., Sánchez, E.E., Campos, R. (1999) The  antihemorrhagic factor of the Mexican ground squirrel (Spermophilus mexicanus). Toxicon 37, 949-954.
  82. Ramirez, M.S., Sánchez, E.E., Garcia-Prieto, C., Perez, J.C., Rodriguez, G., McKeller, M.R., Ramirez, R., DeAnda, Y. (1999) Screening for fibrinolytic activity in eight Viperidae venoms. J Comp.  Biochem Physiol 124, 91-98.
  83. Pérez, J. C., Sánchez, E. E., (1999) Natural protease inhibitors to hemorrhagins in snake venoms and their potential use in medicine.  Toxicon 37, 703-728.
  84. Sánchez, E. E., Garcia, C., Pérez, J. C., De La Zerda, S. J. (1998) The detection of hemorrhagic proteins in snake venoms using monoclonal antibodies against Virginia opossum (Didelphis virginiana) serum.  Toxicon 36, 1451-1459.

The “*” indicates corresponding author.

Book Chapters

  1. Sánchez, E.E., Rodriguez-Acosta, A., Cantu, E., Guerrero, B. (2010) Antivenoms and Coagulation. In: Kini, R.M., McLane, M.A., Clemetson, K., Markland, F.S., Morita, T., (Eds.), Toxins and Hemostasis From Bench to Bedside, Springer, Dordrecht Heidelberg London New York, pp. 711-721.
  2. Rodriguez-Acosta, A., Guerrero, B., Sánchez, E.E. (2010) The theory of intraspecies variation is not the exception, but simply the rule: the diverse hemostatic activities of snake venoms. In: Kini, R.M., McLane, M.A., Clemetson, K., Markland, F.S., Morita, T., (Eds.), Toxins and Hemostasis From Bench to Bedside, Springer, Dordrecht Heidelberg London New York, pp. 97-112.
  3. Pérez, J. C., Finberg, R., Sánchez, E. E. (2008). Important Considerations in Developing Antivenom. In: Hayes, W.K., Kent, R.B., Cardwell, M.D., Bush, S.P.,  (Eds.), The Biology of Rattlesnakes. Loma Linda University Press, Loma Linda, CA.
Book Reviews
  1. Sánchez, E.E., (2016) [Review of the book Venomous Reptiles & Their Toxins. Evolution, Pathophysiology & Biodiscovery, by B. G. Fry (ed.)].  Herpetological Review, 47 (3): 488-489.

Grants

Ongoing Research Support

Sanchez (PI)                                                                                                                                                                                                                                                                         07/10/2016-02/28/2019

NIH/BMRG  

Viper Resource Center Supplement Proposal to Promote Diversity in Higher Education

$78,818        

Sanchez (PI)                                                                                                             07/27/2015

NIH/BMRG  

A Supplement Proposal for the Acquisition of an Amino Acid Sequencer to Support Research and Education Programs at Texas A&M University-Kingsville.         

$138,880      

Sanchez (PI)                                                                                                  06/01/2014 – 02/28/2019

NIH/BMRG  

Viper Resource Center at Texas A&M University-Kingsville  

$2,548,610  

Sanchez (PI)                                                                                                                 08/29/2014

NIH/BMRG  

A Supplement Proposal for the Acquisition of an Inverted Fluorescence Microscope to Support Research and Education Programs at Texas A&M University-Kingsville.

$49,834.79  

Completed Research Support

Sanchez (Co-PI)                                                                                          09/01/2013 – 08/31/2015

Texas A&M University- Kingsville and Texas A&M University-Kingsville                                                      

Intrasystem Cooperation Contract

“Texas A&M Viper Venomics Program”

$200,000

PI: Peter Davies, MD, Ph.D.

Sanchez (Sub-Contractor)                                                                        10/01/2014 – 03/31/2015

SBIR/DARPA

“Universal Antivenom-Phase I”

$33,000

PI: Mark Shumbera, Ph.D. (AMBiotech)

Sanchez (PI)                                                                                                 05/01/2013 – 04/30/2014

NIH/BMRG  

Viper Resource Center at Texas A&M University-Kingsville  

$402,253

Sanchez (PI)                                                                                                 11/13/2012 – 08/31/2013

TAMUK Council for Undergraduate Research (TCUR), Texas A&M University-Kingsville

Inhibition of Proliferation of a Pancreatic Tumoral Cell Line by Snake Venom Disintegrins.

$3,000

Sanchez (PI)                                                                                                 02/02/2012 – 05/31/2013

University Research Award, Texas A&M University-Kingsville.

Expression and Isolation of Recombinant Crotamines: Their Roles in Ion Channels

$9,950

Sanchez (Co-PI)                                                                                          04/01/2008 – 03/31/2013

NIH/NCRR  

Viper Resource Center at Texas A&M University-Kingsville  

$2,457,401  

Sanchez (PI)                                                                                                 10/15/2011 – 08/31/2012

TAMUK Council for Undergraduate Research (TCUR), Texas A&M University-Kingsville

Inhibition of Angiogenesis by Snake Venom Disintegrins.

$2,000

Sanchez (PI)                                                                                                 12/16/2011 – 05/01/2012

PPOH Equipment Grant, Texas A&M University-Kingsville

BD Accuri C6 Flow Cytometer

$40,000

Sanchez (PI)                                                                                                 01/01/2011 – 05/01/2012

Research and Scholarly Activity Award, College of Arts and Sciences, Texas A&M University-Kingsville.

Applications of Recombinant Snake Venom Derived Components in Hemostatic Disorders

$10,000

Sanchez (PI)                                                                                                 01/01/2006 – 05/01/2007

Laboratorio Silanes/Bioclon

Evaluation of Instituto Bioclon Coralymn TM Coral Snake Antivenoms on Two North American Coral Snake Venoms

$15,000

Sanchez (PI)                                                                                                 01/01/2006 – 05/01/2007

Wyeth Pharmaceutical

Evaluation of Wyeth North American Coral Snake Antivenom on Two North American Coral Snake Venoms

$15,000

Contact Information

National Natural Toxins Research Center
975 W. Avenue B, Kleberg Hall Rm#100
MSC 158 Texas A&M University-Kingsville
Kingsville, Texas 78363-8202
voice: (361) 593-3082
fax:
email: elda.sanchez@tamuk.edu
Personal Website:

This page was last updated on: September 6, 2017