Texas A&M University-Kingsville

Personnel Profile

Dr. Sara Lucena, NNTRC Research Scientist

Sara Lucena.png

Education

UNIVERSITY EDUCATION INSTITUTION:

Central University of Venezuela Medical School
Caracas, Venezuela

  • GRADUATION: 1997

  • DEGREE: Bioanalista (Medical Technologist)

POST-GRADUATE STUDIES INSTITUTION:
Venezuelan Institute of Scientific Research
Caracas, Venezuela

  • DEGREE: PhD in Biochemistry

  • PROJECT: “Action of the Venom of the Lonomia achelous caterpillar on adhesives proteins: Its relation with hemostasis”.

  • GRADUATION: 2005

Pre-Graduate Studies

  • XIII Latin American Congress of Clinical Biochemistry. VIII Venezuelan Congress on Bio-Analysis. X Scientific Meeting of the Venezuelan Society of Specialized Bio- Analysts.1997.

  • Society of Bio-Analysts of Vargas Hospital in Caracas. Course on Corporal Fluids .1996.

  • Venezuelan Society on Infectology and Federal District Medical College. Simposium on Tropical Infections in children.1996.

  • First Scientific Meeting of the Tamanaco Urological Laboratory.1996.

  • Venezuelan Society of Infectology. New frontiers in Systemic Mycosis.1995.

Experience

Bioanalista (Medical Technologist)

  • Santa Sofia Clinic. El Cafetal

  • August- September 1998

Bioanalista (Medical Technologist)

  • Miguel Pérez Carreño General Hospital

  • July-August 1998

Bioanalista (Medical Technologist)

  • Otorhinolaryngology Institute in San Bernardino.

  • June- July 1998.

Posdoctoral Fellowship
Venezuelan Institute of Scientific Research

  • 2005-2008

Research Scientist
National Natural Toxins Research Center - Texas A&M University-Kingsville

  • 2008- Present

Awards/ Honors

SCHOLARSHIPS:

  • FUNDAYACUCHO Credit-Scholarship. 1999-2003

  • IVIC Contingency Scholarship. 2003-2004

HONORS:

  • Honours for the research project to obtain the degree of Licentiate in Bio-Analysis: “Determination of oxidized Anti-HDL, LDL and anti-fibronectin antibodies in type II diabetic patients”
  • Lucena S, Salazar A, Gil A, Arocha Piñango C.L., Guerrero B. Award for the best work presented at the IX Congress Venezuelan of Hematology. 2007. Porlamar, Venezuela, entitled: “Effect of Lonomia achelous caterpillar venom on fibronectin functional properties”.

Presentations

  1. Lucena S, Salazar AM, Gil A, Arocha-Piñango CL, B Guerrero. “Effect of the Lonomin V (protease isolated from Lonomia achelous caterpillar hemolymph) on platelet functional properties”. XX Congress Latinoamerican of Hemostasis and Thrombosis (CLATH Group). VIII Congress Argentin of Hemostasis and Thrombosis (CLATH Group). 2008. Buenos Aires, Argentina
  2. I Aguilar, B Guerrero, AM Salazar, S Lucena, ME Girón, EE Sánchez, A Rodríguez-Acosta. “Metaloprotease activities in the venom of South American rattlesnake, Crotalus durisus cumanensis, with action on adhesive proteins of the hemostasis”. XX Congress Latinoamerican of Hemostasis and Thrombosis (CLATH Group). VIII Congress Argentin of Hemostasis and Thrombosis (CLATH Group). 2008. Buenos Aires, Argentina
  3. AM Salazar, I Aguilar, A Rodríguez-Acosta, ME Girón, CL Arocha Pinango, S Lucena, EE Sánchez, J Pérez, B Guerrero. “Activity of protease inhibitors on hemostatic activities in South American venom (Crotalus durisus cumanensis)”. XX Congress Latinoamerican of Hemostasis and Thrombosis (CLATH Group). VIII Congress Argentin of Hemostasis and Thrombosis (CLATH Group). 2008. Buenos Aires, Argentina
  4. B Guerrero, M Da Silva, I Aguilar, S Lucena, AM Salazar, ME Giron, EE Sanchez, J Pérez, M Garcia, A Rodríguez-Acosta. “Cumanastatin-1: Desintegrin isolated from South American rattlesnake Crotalus durisus cumanensis”. XX Congress Latinoamerican of Hemostasis and Thrombosis (CLATH Group). VIII Congress Argentin of Hemostasis and Thrombosis (CLATH Group). 2008. Buenos Aires, Argentina
  5. Lucena S, A Gil, AM Salazar. CL Arocha-Piñango, A Rodriguez-Acosta, B Guerrero. Action of Lonomin V (Lonomia achelous) on fibronectin functional properties. 9th Pan American Section Congress of the International Society of Toxinology. 2007. Juriquilla, México
  6. B Guerrero, M Da Silva, I Aguilar, S Lucena, AM Salazar, ME Girón, E Sánchez, M García, A Rodríguez -Acosta. Inhibition of platelet adhesion induced by a disintegrin from the Venezuelan snake Crotalus durissus cumanensis venom. 9th Pan American Section Congress of the International Society of Toxinology. 2007. Juriquilla, México
  7. I Aguilar, S Lucena, AM Salazar, B Guerrero, ME Girón, E Sánchez, JC Pérez, A Rodríguez - Acosta. The isolation of a fibrinolytic enzyme from the venezuelan rattlesnake Crotalus durissus cumanensis venom. 9th Pan American Section Congress of the International Society of Toxinology. 2007. Juriquilla, México
  8. Da Silva M, García-Casal MN; Rodríguez-Acosta FA; Aguilar I; Lucena S; Guerrero B. Effect of the Venezuelan snake Crotalus durissus cumanensis venom on platelet adhesion. IX Congress Venezuelan of Hematology. 2007. Porlamar, Venezuela
  9. Lucena S., Salazar, AM., Gil A., Arocha-Piñango C. "Platelets adhesion to fibrinogen pre-treated with the venom of the Lonomia achelous caterpillar". LVI Annual Convention of ASOVAC.2006. Cumaná, Venezuela
  10. Da Silva M, Guerrero B, Rodríguez-Acosta A, Aguilar I, García Casal M, Lucena S, Navarrete L. “Action of Crotalus durissus cumanensis and Crotalus vegradis snakes venoms on platelet adhesion”. LVI Annual Convention of ASOVAC.2006. Cumaná, Venezuela
  11. Lucena S., Guerrero B., Salazar AM., Gil A., Arocha-Piñango C. “Degradation of extracellular matrix proteins (fibronectin, vitronectin and laminin) by serine-proteinases isolated from Lonomia achelous caterpillar hemolymph. VIII Venezuelan Congress of Hematology. 2005. Caracas, Venezuela
  12. Lucena S., Guerrero B., Salazar AM., Gil A., Carvajal Z., Arocha-Piñango C. “Degradation of Fibronectin by isolated Serine-proteinases of the hemolymph of the Lonomia achelous caterpillar”. II Research and Teaching Meeting. UCV. 2005. Caracas, Venezuela
  13. Lucena S., Guerrero B., Salazar AM., Gil A., Carvajal Z., Arocha-Piñango C. “Degradation of Fibronectin by Serine-proteinases from Lonomia achelous Hemolymph”. VIII Congress of the Brazilian Society of Toxinology/VIII Symposium of the Pan American Section of the International Society on Toxinology. 2004. Río de Janeiro-Brasil
  14. Lucena S., Salazar AM., Gil A., Carvajal Z., Arocha-Piñango C., Guerrero B. “Effect of Lonomins, isolated proteases of the hemolymph of the Lonomia achelous caterpillar on fibronectin and fibrinogen”. III Meeting of the Integrated Graduate Program at the FONACIT. Cellular Biology Area. IVIC 2004. Caracas, Venezuela
  15. Lucena, S., Guerrero, B., Arocha Piñango, CL. Action of the venom of the Lonomia achelous caterpillar on Fibronectin. II Meeting of the Integrated Graduate Programa at the National Fund for Science, Technology and Innovation. Cellular Biology Area. 2003. Caracas, Venezuela
  16. Guerrero B., Salazar AM., Lucena S., Arocha-Piñango CL. Effect of the venom of the Lonomia achelous caterpillar on the platelet adhesion to fibronectin or fibrinogen. XVIII Internacional Congress on Hemostasis and Thrombosis of the Latin American Cooperation Group on Hemostasis and Thrombosis. CLATH Group. 2003. Río de Janeiro-Brasil
  17. Lucena S., Guerrero B., Salazar AM., Arocha-Piñango CL. Action of the venom of the Lonomia achelous caterpillar on fibronectin, vitronectin and laminin. XVIII Internacional Congress on Hemostasis and Thrombosis of the Latin American Cooperation Group on Hemostasis and Thrombosis. CLATH Group. 2003. Río de Janeiro-Brasil
  18. Sánchez, MR.; Adreani, P.; Guerrero, M.; Lucena, S.; Padrón, M.;Giansante, E. Anti-fibronectin antibodies in type II diabetic patiens. XLVIII Annual Convention. Rafael Belloso Chapín University. Venezuelan Association for the progress of Science (ASOVAC). 1998. Maracaibo, Venezuela.

Publications

  1. Sara Lucena, Belsy Guerrero, Ana M. Salazar, Amparo Gil, Carmen L. Arocha-Piñango. “Degradation of Extracellular Matrix Proteins (Fibronectin, Vitronectin and Laminin) by Serine-Proteinases isolated from Lonomia achelous Caterpillar Hemolymph”. Blood Coagulation and Fibrinolysis. 17 (6): 427-35. 2005
  2. Sara Lucena, Belsy Guerrero, Carmen L. Arocha-Piñango. “Fibronectin. Structure and biological activities associated to hemostasis”. Investigación Clínica. 48 (2): 249-262. 2007
  3. Sara Lucena, Ana M. Salazar, Amparo Gil, Carmen L. Arocha-Piñango, Belsy Guerrero. “Effect of the Lonomia achelous Caterpillar on the Functional Properties of the Fibronectin”. Thrombosis Research. 121 (5): 653-61. 2008
  4. Ana M. Salazar, Irma Aguilar, Belsy Guerrero, María E. Girón, Sara Lucena, Elda E. Sánchez, Alexis Rodríguez-Acosta. “Intraspecies differences in hemostatic venom activities of the South American rattlesnakes, Crotalus durissus cumanensis, as revealed by a range of proteases inhibitors”. Blood Coagulation and Fibrinolysis. 19: 525-530. 2008
  5. Manuel Da Silva, Sara Lucena, Irma Aguilar, Alexis Rodríguez-Acosta, Ana M Salazar, Elda E. Sánchez, María E. Girón, Carmen L. Arocha-Piñango, Belsy Guerrero. “ Anti-platelet effect of Cumanastatin-1, a disintegrin isolated from South American Crotalus rattlesnakes”. Thrombosis Research. 5: 731-739. 2009
  6. Elda E. Sánchez, Alexis Rodríguez-Acosta, Rene Palomar, Sara E. Lucena, Sajid Bashir, Julio G. Soto, John C. Pérez. “Colombistatin: a disintegrin isolated from the venom of the South American snake (Bothrops colombiensis) that effectively inhibits platelet aggregation and SK-Mel-28 cells adhesion”. Archives of Toxicology. 83: 271-279. 2008
  7. Ying Jia, Sara Lucena, Esteban Cantu Jr, Elda E. Sanchez, John C. Pérez. cDNA cloning, expression and fibrin(ogen)olytic activity of two low-molecular weight snake venom metalloproteases. Toxicon. 54: 233-243. 2009
  8. Victoria L. Tran, Elda E. Sanchez, Stephanie A. White, Brandon Gaytán, Jason L. Choi, Natalie Chavez, Steven R. Reyes, Sara E. Lucena, Maria Sugarek, John C. Pérez, Shervin Ghorab, Alexis Rodriguez-Acosta, Julio G. Soto. Functional analysis and molecular modelling of r-mojastin and two binding-loop mutants. Toxicon. 56: 391-401. 2010
  9. Elda E. Sánchez, Sara E. Lucena, Steven Reyes, Julio G. Soto, Esteban Cantu, Juan Carlos Lopez-Johnston, Belsy Guerrero, Ana Maria Salazar, Alexis Rodríguez-Acosta, Jacob A. Galán, W. Andy Tao, John C. Pérez. Cloning, Expression, and Hemostatic activities of a Disintegrin, r-Mojastin1, from the Mohave rattlesnake, (Crotalus scutulatus scutulatus). Trombosis Research. 126: e211-e219. 2010
  10. Lucena S, Elda E. Sánchez, John C. Pérez. Anti-metastactic Activity of the Recombinant Disintegrin, r-Mojastin 1, from the Mohave Rattlesnake. Toxicon. 57:794-802. 2011
  11. Takele Teklemariam, Seoane AL, Ramos CJ, Elda E. Sánchez, Sara E. Lucena, John C. Pérez, Mandal SA, Julio G. Soto. Functional analysis of a recombinant PIII-SVMP, GST-acocostatin; an apoptotic inducer of HUVEC and HeLa, but not SK-Mel-28 cells. Toxicon. 57: 646-656. 2011
  12. Belsy Guerrero, Carmen L Arocha-Piñango, Ana M Salazar, Amparo Gil, Elda E Sanchez, Alexis Rodriguez-Acosta, Sara Lucena. The effects of Lonomin V, a toxin from the caterpillar (Lonomia achelous), on hemostasis parameters as measured by platelet function. Toxicon. 58: 293-303. 2011.
  13. Suchitra Khunsap, Narumol Pakmanee, Orawan Khow, Lawan Chanhome, Visith Sitprija, Montamas Suntravat, Sara E. Lucena, John C Perez, Elda E. Sánchez. Purification of a phospholipase A2 from Daboia russelii siamensis venom with anticancer effects. Journal of Venom Research. 2: 42-51. 2011.
  14. Clayton M.C, Bueno R, Gutierrez D.A, Petro C, Lucena S.E., Sánchez E.E, Soto J.G. Recombinant rubistatin (r-Rub), an MVD disintegrin, inhibits cell migration and proliferation, and is a strong apoptotic inducer of the human melanoma cell line SK-Mel-28. Toxicon. 59: 241-248. 2012.
  15. Sara E. Lucena, Jing Yia, Julio G. Soto, Jessica Parral, Esteban Cantu, Jeremy Brannon, Kristina Lardner, Carla J. Ramos, Agustin I. Seoane , Elda E. Sánchez Anti-metastatic activities of a recombinant disintegrin, r-viridistatin 2, derived from the Prairie rattlesnake (Crotalus viridis viridis). Submitted to Toxicon. 2012.

Contact Information

National Natural Toxins Research Center
975 W. Avenue B, Kleberg Hall Rm#109
MSC 158 Texas A&M University-Kingsville
Kingsville, Texas 78363-8202
voice: (361) 593-3794
fax:
email: sara.lucena@tamuk.edu
Personal Website:

This page was last updated on: April 09, 2014