Texas A&M University-Kingsville

Personnel Profile

Dr. John C. Perez, Chair for the Viper Resource Center

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Education

Utah State Univ. Logan, UT. Ph.D. - 1972

  • Bacteriology

Mankato State Univ. Mankato, Minn. MA - 1969

  • Zoology/Gen.

Univ. of Utah, SLC, UT. B.S. - 1967

  • Mol.& Gen.

College of Eastern Utah, Price, UT A.S. - 1965

  • Science

Awards /Honors in Teaching/ Teaching

  • Selected as one of the top ten professors by the Cap and Gown Honor Society at Texas A&I University, 1974 (Teaching Award)
  • Distinguished Research Award 1979, presented by Texas A&I Faculty and the Alumni Association.
  • One of three professors nominated for the Piper Award in 1979 and 1999 at Texas A&I University.
  • Received the Olan Kruse Science Faculty Award at Texas A&I University 1992-1993 and 96-97.
  • Received the first Society for the Advancement of Chicanos and Native Americans in Science (SACNAS) First Annual Undergraduate Institution Mentor Award in 1998.
  • Received the Koch Industries Outstanding Educator Award September 1999.
  • The first recipient of an Undergraduate Institution Mentoring Award sponsored by the Society for Advancement of Chicanos and Native Americans in Science (SACNAS) in 1998.
  • Regents Professor of the Texas A&M System 1999.
  • Founding Director of the Natural Toxins Research Center at Texas A&M University- Kingsville, 2000.
  • Adjunct Professor Wildlife and Fisheries Sciences, Texas A&M University at College Station. 2001.
  • Adjunct Professor, Texas A&M University System Health Science Center. January 2004
  • Selected as the Texas Academy of Science 2004 Distinguished Scientist.
  • Minority Access Role Model Award, 2004
  • Named on the 2004 Hispanic Business List of 100 Most Influential Hispanics in America.
  • Texas House of Representatives recognition for his many accomplishments. February 2005.
  • Selected as one of the 50 Most Important Hispanics in Technology and Business for 2005 by Hispanic Engineer & Information Technology magazine.
  • Selected as one of the 100 Most Important Hispanics in Technology and Business for 2006. Hispanic Engineer Magazine & Information Technology
  • Regents Professor Emeritus, Texas A & M University - Kingsville, Winter 2011

Lecures/Presentations

  • Keynote speaker at South Texas Association of Biologists, 1978. Recombinant DNA.
  • Seminar speaker for the NIH-MBRS program at New Mexico State University, 1978. Natural Resistance of Woodrats to Snake Venom.
  • Seminar speaker for the NIH-MBRS program at the University of Texas at San Antonio, 1980. Natural Resistance of Opossums to Snake Venom.
  • Seminar speaker at Laredo State Junior College 1981. Hemorrhagic Snake Venoms.
  • Keynote speaker at Ricardo Middle School graduation, Ricardo, Texas. 1986.
  • Seminar speaker at FDA Dallas District. 1987. Monoclonal Antibody Production.
  • Seminar speaker for 8th Annual Texas Herpetological Conference, San Antionio, TX. 1988. The Resistance of four species of warm-blooded animals to Western Diamondback Rattlesnake (Crotalus atrox) venom.
  • Seminar speaker at University of Texas at San Antionio. 1988. The Resistance of Warm-Blooded Animals to Snake Venoms.
  • Seminar speaker at the FDA Technological Update For Laboratory Supervisors held in Bethesda, Maryland. 1988. The Production of Monoclonal and Their Application to the FDA.
  • Seminar speaker on Biotechnology sponsored by Texas A&I University and the Office of Agricultural Biotechnology of USDA. Kingsville, Texas. 1988. The Main Points of the Day.
  • Seminar speaker at University of North Texas at Denton. 1989. The Natural Resistance of Mammals to Snake Venoms.
  • Seminar speaker at University of North Iowa. 1989. The Natural Resistance of Four Species of Mammals to Snake venoms.
  • Seminar speaker at California State at Bakersfield. 1989. Potential Uses of Snake Venom as Immunotoxins.
  • Seminar speaker at the Proceedings of the Seventeenth NIH- MBRS Symposium. 1989. The Resistance of four species of warm-blooded animals to Western Diamondback Rattlesnake (Crotalus atrox) venom.
  • Seminar speaker for National Hispanic Heritage Month at the Kingsville Naval Air station. 1990. Education Excellence-Key to Our Future.
  • Seminar speaker at biotechnology training course for the FDA chemist and microbiologists. Philadelphia, Pennsylvania.1991. Monoclonal antibiodies and their characterization.
  • Seminar speaker at Kiev State University. Ukraine USSR. 1992, Monoclonal antibodies and their characterization.
  • Seminar speaker at the FDA Dallas District Conference. Dallas, Texas. 1992. Current and Future Research Issues in Biotechnology.
  • Seminar speaker at Sixth International Congress of Traditional and Folk Medicine. Kingsville, Texas.1992. Natural resistance of Virginia opossum ( Didelphis virginiana) to snake venom.
  • Seminar speaker at the FDA Dallas District Conference. Dallas, Texas. 1993. Current and Future Research Issues in Biotechnology.
  • Seminar speaker at Texas A&M University, College Station, TX. 1995. Natural Resistance to Snake venom by Warm-blooded Animals.
  • Workshop at University Development Day, Using the Internet in the classroom. Texas A&M University-Kingsville.1996.
  • Seminar speaker for the American Chemical Society Annual Meeting in Kingsville, Texas, 1997. The natural resistance of mammals to snake venoms.
  • Seminar speaker at Del Mar College, Corpus Christi, TX. 1997. The natural resistance of mammals to snake venoms.
  • Seminar speaker at the 6th PanAmerican Congress on Animal, Plant and Microbial Toxins. 1998. Margarita Island, Venezuela. Comparison of Viperidae Venoms by High Performance Liquid Chromatography and Proteolytic Assays.
  • Seminar speaker at the Graduate Education for Hispanics in Science and Engineering Conference, University of Illinois at Urbana-Champaign. 2003. An overview of research at Texas A&M University-Kingsville.
  • Seminar speaker at Institute of Bioscience and Technology. Texas A&M Health Science Center in Houston, TX. 2003. Biomedical Applications of Snake Venom.
  • Seminar speaker at the California association of Toxicologist, San Francisco, CA. 2004. Venom Toxin Profiling and the Serpentarium Database.
  • Seminar speaker at the Texas Academy of Science 2004 Distinguished Lecture. 2004 Kerville, TX. Research at the Natural Toxins Research Center (NTRC).
  • Invited speaker at the University of Texas Health Science Center in Houston, June 2004. Animals with a Natural Resistance.
  • Invited speaker at the University of Texas at San Antonio.Venom Research at the Natural Toxins Research Center. September 17, 2004.
  • Invited speaker at the VIIIth Congress of the Brazilian Society of Toxinology and the VIIIth Symposium of the Pan American Section of the International Society on Toxinology, September, A Review of important Considerations in Developing Antivenom. September 2004, Rio de Janeiro, Brazil.
  • Invited speaker at the II Inter-America Workshop on Natural Toxins. Venenos de Serpientes y Metodos Bioquimicos. September 2004. Caracas, Venezuela.
  • Invited speaker at the University of Texas at Brownsville.Biomedical Research at the Natural Toxins Research Center (NTRC). October 15, 2004.
  • Invited speaker at the 7th Reunion Internacional de Expertos en Envenenamiento por Animales Ponzonosos. March 2005. Cuernavaca, Mexico
  • Invited speaker at the Northwest Vista College Science Conference 2005. Biomedical Research at the Natural Toxins Research Center. April 2005.

Publications

  • Khunsap, S., Pakmanee, N., Khow, O., Chanhome, L., Sitprija, V., Suntravat, M., Lucena, S.E., Perez, J.C., Sánchez, E.E. (2011) Purification of a phospholipase A2 from Daboia russelii siamensis venom with anticancer effects. J Venom Res. 2, 42-51.*

  • Lucena, S., Sanchez, E.E., Perez, J.C. (2011) Anti-metastatic Activity of the Recombinant Disintegrin, r-Mojastin 1, from the Mohave Rattlesnake. Toxicon 57, 794-802.

  • Teklemariam, T., Seoane, A.I., Ramos, C.J., Sanchez, E.E., Lucena, S.E., Perez, J.C., Mandal, S.A., Soto, J.G. (2011) Functional analysis of a recombinant PIII-SVMP, GST-acocostatin; an apoptotic inducer of HUVEC and HeLa, but not SK-Mel-28 cells. Toxicon 57, 646-656.

  • Suntravat M, Yusuksawad M, Sereemaspun A, Pérez JC, Nuchprayoon I (2011). Effect of Russell’s viper venom-factor X activator (RVV-X) on DIC, renal hemodynamics and function, and histopathology. Toxicon. 58, 230-238.

  • Sukkapan P, Jia, Y, Nuchprayoon I, Pérez, JC. (2011) Phylogenetic analysis of serine proteases from Russell’s viper (Doboia russelli siamensis) and Agkistrodon piscivorus leucostoma venom. Toxicon. 58, 168-178.

  • Jia, Y., Perez, J. C., 2009c. Molecular cloning and characterization of cDNAs encoding metalloproteinase from snake venom glands. Toxicon. 55 (2-3):462-9.

  • Jia, Y., Lucena, S., Cantu, E., Sánchez, E.E., Pérez, J.C. (2009) cDNA cloning, expression and fibrin(ogen)olytic activity of two low-molecular weight snake venom metalloproteinases. Toxicon 54:233-243.

  • Jia, Y., Perez, J. C., 2009a. Recombinant expression and affinity purification of snake venom gland parvalbumin in Escherichia coli. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 153: 303-308.

  • Sánchez, E.E., Rodriguez-Acosta, A, Palomar, R., Lucena, S.E., Bashir, S., Soto, J.G., Pérez, J.C. (2009) Colombistatin: a disintegrin isolated from the venom of the South American snake (Bothrops colombiensis) that effectively inhibits platelet aggregation and SK-Mel-28 cell adhesion. Arch Toxicol. 83:271-279.

  • Salazar, A.M., Guerrero, B., Cantu, B., Cantu, E., Rodríguez-Acosta, A., Perez, J.C., Galan, J.A., Tao, A., Sánchez, E.E. (2008) Venom variation in hemostasis of the southern Pacific rattlesnake (Crotalus oreganus helleri): Isolation of hellerase. Comp Biochem Physiol C Toxicol Pharmacol. 149:273-277.

  • Pornmanee, P., Perez, J.C., Sánchez, E.E., Khow, O., Pakmanee, N., Chulasugandha, P., Chanhome, L., Petsom, A. 2008) pH gradient electrophoresis and biological activity analysis of proteins from Malayan pit viper (Calloselasma rhodostoma) venom. ScienceAsia 34:273-277.

  • Pornmanee, P., Sánchez, E.E., López, G., Petsom, A., Khow, O., Pakmanee, N., Chanhome, L., Sangvanich, P., Pérez, J.C. (2008) Neutralization of lethality and proteolytic activities of Maylayan pit viper (Calloselasma rhosdostoma) venom with North American Virginia Opossum (Didelphis virginiana) serum. Toxicon. 52: 186-189.

  • Jia, Y., Cantu, B., Sánchez, E.E., Pérez, J.C. (2008) Complementary DNA sequencing and identification of mRNAs from venomous gland of Agkistrodon piscivorus leucostoma. Toxicon 51:1457-1466.

  • Galán, J.A., Sánchez, E.E., Rodríquez-Acosta, A., Soto, J.G., Bashir, S., McLane, M.A., Paquette-Straub, C., Pérez, J.C. (2008) Inhibition of lung tumor colonization and cell migration with the disintegrin crotatroxin 2 isolated from the venom of Crotalus atrox. Toxicon 51:1186-1196.

  • Galán, J.A., Guo, M., Sánchez, E.E., Cantu, E., Rodríguez-Acosta, A., Pérez, J.C., Tao, W.A.(2008) Quantitative analysis of snake venoms using soluble polymer-based isotope labeling. Mol Cell Proteomics. 7:785-799.

  • Sánchez, E.E., Lopez-Johnston, J.C., Rodríguez-Acosta, A., Pérez, J.C. (2008) Neutralization of two North American coral snake venoms with United States and Mexican antivenoms. Toxicon. 51(2), 297-303.

  • Girón, M.E., Salazar, A.M., Aguilar, I., Pérez, J.C., Sánchez, E.E., Arocha-Piñango, C.L., Rodríguez-Acosta, A., Guerrero, B., (2007) Hemorrhagic, Coagulant and Fibrino(geno)lytic Activities of Crude Venom and Fractions from Mapanare (Bothrops colombiensis) snakes. Comp. Biochem. Phys. Part C. 147, 113-121.

  • Aguilar, I., Guerrero, B., Salazar, A.M., Girón, M.E., Pérez, J.C., Sánchez, E.E., Rodriquez-Acosta, A. (2007) Rattlesnake Crotalus durissus cumanensis venom variability: coagulant, fibrino(geno)lytic, hemorrhagic and lethal activities. Toxicon. 50, 214-224.

  • Pérez, J. C., Finberg, R., Sánchez, E. E. (In Press). Important Considerations in Developing Antivenom. In: Bush, S.P. (Ed.), Biology of the Rattlesnakes.

  • Rodríguez-Acosta, A., Magaldi, S., Pérez, J.C., Sánchez, E.E., Girón, M.E., Agular, I. (2007) A protein homology detection between rattlesnakes (Viperidae: Crotalinae) from South and North America deduced from antigenically related metalloproteases. Animal Biology 57, 401-407.

  • Soto, J.G., White, S.A., Reyes, S.R., Regalado, R., Sánchez, E.E., Pérez, J.C. (2006) Molecular evolution of PIII-SVMP and RGD disintegrin genes from the genus Crotalus. Gene DOI: (http://dx.doi.org/10.1016/j.gene.2006.09.020).

  • Soto J. G., Powell, R.L., Reyes, S.R., Wolana, L., Swanson, L.J., Sánchez, E.E., Pérez J. C. (2006) Genetic variation of a disintegrin gene found in the American copperhead snake (Agkistrodon contortrix). Gene 373, 1-7.

  • Powell, R. L., Sánchez, E.E., Perez, J. C. (2006) Farming for venom: Survey of snake venom extraction facilities worldwide. Applied Herpetology 3, 1-10.

  • Sánchez, E.E., Galán, J. A., Soto, J. G., Russell, W. K., Russell, D. H., Pérez, J. C. (2006) Isolation and Characterization of Two Disintegrins Inhibiting ADP-Induced Human Platelet Aggregation From The Venom of Crotalus scutulatus scutulatus (Mohave Rattlesnake). Toxicol. Appl. Pharmacol. 212, 59-68.

  • Sánchez EE, Galán, JA, Powell RL, Reyes SR, Soto JG, Russell WK, Russell DH, Perez, JC.In Press, March 2005. Disintegrin, hemorrhagic, and proteolytic activities of Mohave rattlesnake,Crotalus scutulatus scutulatus venoms lacking Mojave toxin. Comparative Biochemistry and Physiology Part C.

  • Galán JA, Sánchez EE , Bashir S, Pérez JC. "Crotalus horridus venom by liquid chromatography and tandem matrix-assisted laser desorption ionization quadrupole ion trap time-of-flight (MALDI-QIT-TOF) mass spectrometry". The Canadian Journal of Chemistry. 

  • McLane, M.A., Sánchez, E.E., Wong, A., Paquette-Straub, C., Pérez, J.C., 2004. Disintegrins. Current Drug Target-Cardiovascular and Haemotological Disorders.

  • Galán, J.A., Sánchez, E.E., Rodríquez-Acosta, A., Pérez, J.C., 2004. Neutralization of venoms from two Southern Pacific Rattlesnakes (Crotalus helleri) with commercial antivenoms and endothermic animal sera. Toxicon 43: 791-799.

  • Caraballo,A., Navarro, J., Sanchez, EE, Perez, JC., Rodriguez-Acosta, A., 2004. Epidemiological and clinical aspects of snakebites in Bolivar State, Venezuela. Revista de la Facultad de Medicina, 27, 25-28.

  • Navarro, J., Caraballo, A., Sánchez, E., Pérez, J.C., Rodriguez- Acosta, A., 2003. Epidemiological and clinical aspects of snakebites in Monagas State, Venezuela. Revista de la Facultad de Medicina 26, 100-104.

  • Sanchez, E.E., Ramirez, M.S., Galan, J.A., Lopez, G., Rodriguez-Acosta, A., Perez, J.C., 2003. Cross reactivity of three antivenoms against North American snake venoms. Toxicon 41 315-320.

  • Sanchez, E.E., Galan, J.A., Perez, J.C., Rodriguez-Acosta, A., Chase, P.B., Perez, J.C., 2003. The efficacy of two antivenoms against the venom of North American snakes. Toxicon 41 357-365.

  • McKeller, M.R., Pérez, J. C., 2002. The effect of Western Diamondback Rattlesnake (Crotalus atrox) venom on the production of antihemorrhagins and /or antibodies in the Virginia opossum (Didelphis virginiana). Toxicon 40, 427-439.

  • Sanchez E.E., Soliz, L.A., Ramirez, M.S., Pérez, J.C., 2001. Isolation and characterization of a basic protein from Crotalus molossus molossus venom. Toxicon 39, 523-537.

  • Perez J. C., McKeller, M.R., Pérez, J. C., Sánchez, E. E., Ramirez, M.S., 2001. An internet database of crotaline venoms found in the United States. Toxicon 39, 621-632.

  • Pérez, J. C., Sanchez, E. E. 1999. Natural protease inhibitors to hemorrhagins in snake venoms and their potential use in medicine. Toxicon 37, 703-728.

  • Ramirez, M.S., Sanchez, E.E., Garcia-Prieto, C., Perez, J.C., Rodriguez, G., McKeller, M.R., Ramirez, R., DeAnda, Y., 1999. Screening for fibrinolytic activity in eight Viperidae venoms. J. Biochem Physiol 124, 91-98.

  • Martinez R.R., Pérez, J.C., Sanchez, E.E., Campos, R,. 1999. The antihemorrhagic factor of the Mexican ground squirrel (Spermophilus mexicanus). Toxicon 37, 949-954.

  • Sanchez, E. E., Garcia, C., Pérez, J. C., De La Zerda, S. J., 1998. The detection of hemorrhagic proteins in snake venoms using monoclonal antibodies against Virginia opossum (Didelphis virginiana) serum. Toxicon 36,1451-1459.

  • Noah, C. W., Poteet, S. S., Ramos, N. C., Pérez, J. C., Huang, S. Y., 1995. Production of monoclonal antibodies specific to Clostridium botulinum Type B neurotoxin. Journal of AOAC International 78, 795-799.

  • Rael, E. D., Lieb, C. S., Maddux, N., Arela-Ramirez, A., Pérez, J. C., 1993. Hemorrhagic and mojave toxins in the venoms of the offspring of two mojave rattlesnakes (Crotalus scutulatus scutulatus). Comp. Biochem. Physiol. 106B, 595-600.

  • Analia, M., Rael, E. D., Lieb, C., Pérez, J. C., Salo, R. J., 1992. Antibody detection of venom protein variations within the population of the rattlesnake (Crotalus v. viridis). Journal of Herpetology 26, 473-482.

  • Huang, S. Y., Pérez, J. C., Rael, E. D. Lieb, C. Martinez, M. Smith, S. A., 1992. Variation in the antigenic characteristics of venom from the Mojave Rattlesnake (Crotalus Scutulatus scutulatus). Toxicon 30,387-396.

  • Noah, C. W., Pérez, J. C., Ramos, N. C., McKee, C. R., Gipson, M. V., 1991. Detection of Listeria spp. In naturally contaminated seafoods using four enrichment procedures. Journal of Food Protection 54,174-177.

  • Adame, B. L., Soto, J. G., Secraw, D. J. Pérez, J. C., Glenn, J. L., Straight. R. C., 1990. Regional variation of Biochemical characteristics and antigeneity in Great Basin rattlesnake (Crotalus viridis lutosus). Comp. Biochem. Physiol. 97B,95-101.

  • Martinez, R. A., Huang, S. Y. Pérez, J. C.,1989. Antigenic relationships of fractionated western diamondback rattlesnake (Crotalus atrox) hemorrhagic toxins and other rattlesnake venoms as indicated by monoclonal antibodies. Toxicon 27,239.

  • Soto, J. G., Pérez, J. C., Lopez, M. M., Martinez, Quintanilla- Hernandez, M. T. B., Santa-Hernandez, M. S., Turner, K., Glenn, J. L. Minton, S. A., 1989. Comparative enzymatic study of HPLC-fractionated Crotalus venoms. Comp. Biochem. Physiol. 93B, 847-855.

  • McKee, C. R., Pérez, J. C., Gipson, M. V., Noah, C. W., Yetts, S. Y., 1989. Detecting Listeria spp. In food samples using the gene- track isotopic Listeria assay DNA hybridization procedure and the FDA cultural procedure. Laboratory Information Bulletin. 5,3348.

  • Soto, J. G., Pérez, J. C., Minton. S. A., 1988. Survey of proteolytic, hemorrhagic, and hemolytic activities of forty snake venoms. Toxicon 26,875-882.

  • Tarng, S., Huang, S. Pérez, J. C., 1986. Isolation of antihemorrhagic factors in opossum (Didelphis virginiana) serum with a monoclonal antibody immunoadsorbent. Toxicon 15, 567-573.

  • Garcia, V., Pérez, J. C., 1984. The purification and characterization of an antihemorrhagic factor in woodrat (Neotoma micropus) serum. Toxicon 22,129-137.

  • Pérez, J. C., Garcia, V. E., Huang.,S. 1984. Production of a monoclonal antibody against hemorrhagic activity of Crotalus atrox (western diamondback rattlesnake) venom. Toxicon 22,967-973.

  • Huang, S., Pérez J. C., 1982. A comparative electron microscopic study of myonecrosis induced by Crotalus atrox (western diamondback rattlesnake) in gray woodrats and mice. Toxicon 20,443-449.

  • Pichyangkul, S., Pérez, J. C.,1981. Purification and characterization of a naturally occurring antihemorrhagic Factor in the serum of the Hispid Cotton Rat (Sigmodon hispidus). Toxicon 19, 205-215.

  • Menchaca, J., Pérez, J. C., 1981. The purification and characterization of an antihemorrhagic factor in opossum (Didelphis virginiana) serum. Toxicon 19,623-632.

  • Pérez, J. C., Huang., S., 1980. Comparative study on hemorrhagic and proteolytic activities of snake venoms. Toxicon 18, 421-426.

  • Huang, S., Pérez, J. C., 1980. Comparative study on hemorrhagic and proteolytic activities of snake venoms. Toxicon 18,421-427

  • Pérez, J. C., Huang, S., Menchaca., J., 1979. Natural resistance of certain snakes, opossum and woodrats against snake envenomation. TAIUS 12,49-57.

  • Neas, E., Pérez, J. C., 1979. Growth of BHK-21 cells in a mas culture system. Texas J. Sci. 31, 65-74.

  • Pérez, J. C., Pichyangkul, S., Garcia., V. E., 1979. The resistance of three species of warm-blooded animals to western diamondback rattlesnake (Crotalus atrox) venom. Toxicon 17, 601-607.

  • Pérez, J. C., Haws, W. C., Hatch C., 1978. Resistance of woodrats to Crotalus atrox venom. Toxicon 16,199-211.

  • Pérez, J. C., Haws, W. C., Garcia,V. E., Jennings, III B. M., 1978. Resistance of warm-blooded animals to snake venom. Toxicon 16,375-383.

  • Pérez, J. C., 1972. Radioimmuno detection of viral antigen. Bacteriological. Proc. 72:190.

Contact Information

National Natural Toxins Research Center
975 W. Avenue B, Kleberg Hall
MSC 158 Texas A&M University-Kingsville
Kingsville, Texas 78363-8202
voice: (361) 593-3805
fax:
email: john.perez@tamuk.edu
Personal Website:

This page was last updated on: April 09, 2014