Ph.D. Organic Chemistry,
University of Texas at Austin: 1982
M.S. Chemistry, I. I.T. Kanpur, India: 1976
B.S. Chemistry, Calcutta University, India: 1974
Office: N205
Phone: (361) 593-2664
Mailing Address: 920 W. Santa Gertrudis
Kingsville, TX 78363
E-mail address: kfab002@tamuk.edu
Professional Experience
2008-Present Associate
Professor, Texas A&M Kingsville
2007-2008 Senior Vice President.
Dr. Reddy’s Laboratories, India.
2006-2007 Vice President, Head
of Global Research & Development; Dr. Reddy’s Laboratories,
India.
2004-2006 Tenured, Associate
Professor
1999-2004 Assistant Professor,
Texas A&M University, Kingsville.
1997-1999 Group Leader, Bristol
Myers Squibb, Central Process Research
1995-1997 Lead Chemist; Innovator
Group, Hoechst.
1994-1995 Staff Chemist, Hoechst-Celanese.
1990-1994 Senior Research Chemist,
Hoechst-Celanese.
1988-1990 Research Fellow, Process
Research and Development, Merck & Co., Inc.
1983-1988 Senior Research Chemist,
Process Research and Development, Merck & Co., Inc.
10-02-2004
Pharm Tech - In the Field - Production Process
Increases Productivity
07-06-2004
Bridges program offers students road to success
06-15-2004
Professor
to speak at annual symposium
.09-05-2003.
Texas A&M University-Kingsville paves way to Ph.D.s
(Corpus
Christi Caller Times)
09-03-2003
Chemistry Bridges to Doctoral Grant
10-14-2002
Professor
Simplifies Tylenol Production (Corpus
Christi Caller Times)
08-01-2002
A&M-Kingsville has partnership with drug
industry (Corpus Christi
Caller Times)
07-23-2001
Education Concentrates
(Chemical
& Engineering News)
06-21-2001
Graduate Students
Intern at Bristol-Meyers Squibb (TAMUK
Press Release)
11-01-1999
Renowned
chemist sharing his vision (Corpus Christi Caller Times)
Dr. Bhattacharya's Organic and Environmental Research
Meet Dr. Bhattacharya's Research Group
Current Students Former Students
Course Syllabi:
Advanced Organic Synthesis Physical Organic Chemistry Asymmetric Synthesis Graduate Seminar Green Chemistry CHEM 3323 CHEM 3325
Consultant:
A. Advisory Board for the Clinton Foundation HIV/AIDS Initiative (CHAI)
B. Member of the National Academies’ Chemical Sciences Roundtable (CSR). This is a committee of advisors that reports its recommendation of the directions of US Science to the US Congress and the President.
C. Member: Panel of Drug Evaluators for Current Drugs (CD). Responsible for the evaluation of drugs, which are being launched worldwide under FDA guidelines.
C. Scientific Process Advisor:
1. Dr
Reddy’s Laboratories. Hyderabad, India.
2. PHARM-ECO A Johnson Matthey
Company
3. Texas Bio Technology.
4. Bristol
Myers Squibb Pharmaceutical Co.
5. Boehringer-Ingelheim
Pharmaceutical.
6. Johnson & Johnson
Pharmaceutical Research & Development.
7. Ambion.
8. National Advisory Committee, Osmania University, India.
D. Consultant:
1. Senator Kay Bailey Hutchison’s
List of Designated Expert in Environmental Chemistry .
2. Corpus Christi Regional Economic Development Corporation
E. Advisory Board Member: Chembiotek, India.
F. Advisor: NIH: SSS-L study section, SBIR/STTR applications in Drug Discovery, Development and Delivery.
G. Director, NIH Texas Bridges to Doctorate Program.
Doctoral Work:
University of Texas at Austin.
Asymmetric induction in carbon-carbon bond forming reactions. Kinetic
resolutions. Chiral Diels Alder reaction. Asymmetric synthesis of
natural product.
Current Research:
Green chemistry.
Designing environmentally benign/waste-free chemistry with special
emphasis towards current industrial synthesis and processes utilizing
homogeneous and heterogeneous catalyst systems.
Asymmetric synthesis.
Chiral Phase Transfer Catalysis.
Recent Publications:
1. "Temperature Selective Diastereo-Recognition (TSD): Enantiomeric Ibuprofen via Environmentally Benign Selective Crystallization". Organic Process Research Development" 7, 5, 717, 2003.
2. "Benzoin Condensation: Monitoring a Chemical Reaction by High Pressure Liquid Chromatography". Journal of Chemical Education, 81, 7 1020-2, 2004.
3. "An Efficient Conversion of Nitriles to Amides: Application in the Synthesis of N,N-Diethyl-p-toluamide (DEET(tm)). Tetrahedron Letters 47, 505, 2006.
4. "Surfactant-Mediated Solvent-Free Dealkylative Cleavage of Ethers and Esters and Trans-Alkylations under Neutral Conditions" Tetrahedron Letters 47, 565, 2006.
5. "One-Step Reductive Amidation of Nitro-Arenes: Application in the Synthesis of Aceaminophen(tm))" Tetrahedron Letters 47, 1861, 2006.
6. "Eco-friendly reductive acetamidation of arylnitro compounds by thioacetate anion through in situ catalytic re-generation: application in the synthesis of acetaminophenTM"
7. Tetrahedron Letters 47, 3221, 2006.
8. "Remarkable Solvent Effect in Barton-Zard Pyrrole Synthesis: Application in an Efficient One-Step Synthesis of Pyrrole Derivatives". Tetrahedron Letters, 47, 31, 5421, 2006.
9. " Pseudo-Enzymatic Catalyst-Substrate Interactions in Ion-Pair Mediated Chiral Phase Transfer Catalysis". Tetrahedron Letters 47, 31, 5581, 2006.
10. "An Efficient Electrophilic N-Amination Utilizing in situ Generated Chloramine Under Phase Transfer Conditions". Tetrahedron Letters 47, 30, 5341, 2006.
11. "Preparing the Next Generation of Research Scientists" American Chemical Society: Petroleum Research Fund Publication, 2006.
12. "An Improved Process for Repaglinide via an Efficient and One Pot Process of (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine - A Useful Intermediate". CHIMIA International Journal for Chemistry, Volume 60, Number 9, pp. 593-597(5), September 2006.
13. "Substrate Modification Approach to Achieve Efficient Resolution: Didesmethylcitalopram-A Key Intermediate for Escitalopram" Organic Process Research Development 11(2), 289-292, 2007.
14. "An Efficient and Impurity-Free Process for Telmisartan: An Antihypertensive Drug". Organic Process Research & Development, 11(1), 81-85, 2007.
15. "Efficient synthesis of (1R)-[3,5-bis (trifluoromethyl) phenyl] ethanol; a key intermediate for aprepitant, an NK-1 receptor antagonist". Synthetic Communications. 37: 3439-3446, 2007.
16. "(S)-3-(Aminomethyl)-5-methylhexanoic acid (Pregabalin)". Acta Cryst. Section C, C63, o306±o308, 2007.
17. "An Alternative Approach to Achieve Enantiopure (3S)-4-Benzyl-3- (4-fluorophenyl)morpholin-2-one: A Key Intermediate of Aprepitant, an NK1 Receptor Antagonist" Organic Process Research & Development. 11(3), 455-457, 2007.
18. "Effect of Solvent on Stereoselectivity in Pd-C (Type-39K) Catalyzed
19. Hydrogena-tion of Methyl 3-oxo-4-aza-5-?-androstene-17-carboxylate- A
20. Key Intermediate for Finasteride and Dutasteride". Organic Process Research & Development, 11(5); 889-891, 2007.
21. "An Alternate Route to 2-Amino-3-Nitro-5-Bromo Picoline: Regioselective Pyridine Synthesis via 2-Nitramino Picoline Intermediate". Organic Process Research & Development, 11(5); 885-888. 2007. [Top ten most downloaded paper in 2007]
22. "An Improved Synthesis of Rimonabant: Anti-obesity Drug" Organic Process Research & Development, 11(5), 910-912, 2007. [Top ten most downloaded paper in 2007]
23. "A convergent approach to the synthesis of aprepitant: A potent human NK-1 receptor antagonist" Tetrahedron Letters. 48, 8001-8004, 2007.
24. "Total synthesis of (-)-galanthamine hydrobromide". Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007,
25. "Boric Acid Cataylyzed Amidation in the synthesis of Active Pharmaceutical Ingredients" Organic Process Research & Development, 11(6); 1065-1068, 2007.
26. "Boric Acid: An Efficient and Environmentally Benign Catalyst for
27. Transesterification of _-Keto Esters" 49, 106-109, Tetrahedron Letters. 2008.
28. "An Expeditious Synthesis of Ramipril: an Angiotensin Converting Enzyme (ACE) Inhibitor#" Synthetic Communications 38(11), 1737-1744, 2008.
29. "An Investigation on Key Parameters That Influence the Resolution of Omeprazole Sodium?" Organic Process Research & Development, 12(1), 66-68. 2008.
30. "An alternative total synthesis of (-)-galanthamine hydrobromide" Synthetic Communications 38: 2138-2149, 2008.
31. "Synthesis of Rimonabant Regioisomer" Monatshefte fur Chemie - Chemical Monthly, 139(9), 1091-1093, 2008.
32. "A Novel Synthesis of Fosphenytoin: Anti-convulsant Prodrug" Synthetic Communications 38(17), 2950-2957, 2008.
33. "A Non-infringing Synthesis of Simvastatin: HMG-CoA Reductase Inhibitor" Synthetic Communications 2008 (in press).
34. "An Alternative Synthesis of Tadalafil: PDE5 Inhibitor" Synthetic Communications, 38(23), 4265-4271, 2008.
35. "Reaction of Finasteride Intermediate with Benzeneseleninic Anhydride: An In-depth Study" Industrial & Engineering Chemistry Research 47(23), 9201-9205, 2008.
36. "An improved process for eszopiclone: anti-insomnia agent" Organic Communications. 1(2), 33-38, 2008.
37. "Borid acid catalyzed environmentally benign amidation and esterification processes in the synthesis of active pharmaceutical ingredients". Abstracts of Papers, 236th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008.
38. "Synthesis of quinoline analogs. Search for antimalarial agents". Monatshefte fuer Chemie. 139(2), 179-181, 2008.
39. "Efficient Synthesis of Olmesartan Medoxomil, an Antihypertensive Drug" Synthetic Communications, 39 (2): 291-298, 2009.
40. "Novel synthesis of fosphenytoin. anti-convulsant prodrug". Synthetic Communications. 39(4), 748. 2009.
41. Ab initio structure determination of anhydrous sodium alendronate from laboratory powder X-ray diffraction data. Journal of Pharmaceutical Sciences 98(6), 2113-2121, 2009.
42. Preparative Chromatography Technique in the Removal of Isostructural Genotoxic Impurity in Rizatriptan: Use of Physicochemical Descriptors of Solute and Adsorbent. Organic Process Research & Development, ACS ASAP. 2009.
43. "Green Technologies in the Generic Pharmaceutical Industry" An invited Book Chapter "Green Chemistry in the Pharmaceutical Industry" to be published, John Wiley & Sons, 2009.
44. "Green Chemistry in Drug Discovery and Process Research" an invited review article to be published in Current Opinion in Drug Discovery & Development. Manuscript submitted.
Recent Patents :
1. "Process for azole antifungal intermediates" U.S. 6,326,509, Dec.4, 2001.
2. "Method of Producing Organic Compounds in the Presence of Oxyethylene Ether Catalyst and in a Solvent Minimized Environment" issued Nov. 29, 2005. US Patent No. 6,969,775.
3. "Preparation of 4-(2-Bromoethoxy)phenol". Patent applied in collaboration with Johnson & Johnson (2003 pending).
4. "Method for preparing pyrrolotriazine compounds via amination of pyrroles with in situ generated chloramines" U.S. Pat. Appl. Publ. (2006), 9pp. CODEN: USXXCO US 2006229449 A1 20061012 Patent written in English. Application: US 2006-396888 20060403. Priority: US 2005-668765 20050406. CAN 145:419185 AN 2006:1070156
5. "Process for preparation of 2-amino-5-bromo-4-methyl-3-nitropyridine". U.S. Pat. Appl. Publ. (2007), 6pp. CODEN: USXXCO US 2007032657 A1 20070208 Patent written in English. Application: US 2006-492730 20060725. Priority: US 2005-705261 20050803. CAN 146:229188
6. "One Pot Reductive Acetaminidation of Aryl Nitro Compounds", issued Feb. 7, 2007. US Patent No. 7,173,152,
7. "Purification process using co-crystal approaches"-US provisional application 60/827,259 on 28 Sep 2006
8. "Preparation of Fosphenytoin sodium" - US 2007/0249563A1
9. "Process for preparing fosphenytoin". U.S. Pat. Appl. Publ. US 2007249563. 2007.
Recent Published Abstracts and Meeting Proceedings:
1. "Development of Finastride".: 2001 4th Annual Howard Radwin Urology Conference San Antonio Medical Center. Texas October 19-20, 2001
2. "Environmentally Friendly Solvent-Free Processes: Preparation of Nitro Alcohols, A Class of Valuable Drug Intermediates by Henry Reaction".: American Chemical Society 57th Southwest Regional Meeting October 17-20, 2001, San Antonio, Texas.
3. "Environmentally Friendly Solvent Free Processes: Application of a novel surfactant induced dual catalysis in Henry Reaction". 6th Annual Green Chemistry and Engineering Conference Washington, D.C. June 24-27, 2002.
4. "Environmentally Friendly Solvent Free Processes: Application of a novel surfactant induced dual catalysis in the Preparation of Pharmaceutical Intermediates". Tenth Annual Coastal Bend Environmental Conference, Kingsville, Texas, October 30-Nov 1, 2002.
5. "Bridging Process Research and Development: from Academia to Industry"
6. Pharm-Eco John Matthey, February 20, 2002.
7. "Bridging Green Chemistry to Industry" Sepracor Inc; February 20, 2002.
8. "Green Chemistry in Texas A&M Kinsville". Johnson & Johnson Pharmaceutical Research & Development. March 28, 2003.
9. "Process Research and Development: From Academia to Industry". University of Texas Medical Branch, Galveston Medical Center. March 30, 2003.
10. "Intermediacy in Quinone Oxidation" The University of Texas-Pan American. April 10, 2003.
11. "Applications in Green Technology" October 22, 2003. Environmental Engineering Seminar. Texas A&M Kingsville.
12. "Temperature Selective Diastereo-Recognition (TSD): Enantiomeric Ibuprofen via Environmentally Benign Selective Crystallization". South Texas Section, American Chemical Society, Second Research Symposium, Kingsville, Texas, November 21, 2003.
13. "Process Development studies of a BPH Candidate" Ranbaxy Pharmaceutical, Delhi, India, January 6, 2004.
14. "Drug Developmental studies of Azasteroids" Astra Zeneca Pharmaceutical, Bangalore, India, January 9, 2004.
15. "Process Developmental Studies of Pharmaceutical Intermediate in Texas A&M University-Kingsville, Dr. Reddy's Lab, India, January 12, 2004.
16. "The Role of Bristol-Myers Squibb in Educating the Next Generation: Process R&D at Texas A&M Kingsville. Part I
17. Development of Proscar. Part II". Bristol Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ, February 20, 2004.
18. "Process Research and Development in Texas A&M Kingsville: Educating the Next Generation". Novartis Pharmaceutical. East Hanover, NJ, February 19, 2004.
19. "Application of Quinone oxidation in developing and alfa reductase inhibitor candidate". Ambion Pharmaceutical, Austin Texas. April 1, 2004.
20. "Development of a BPH candidate: Synthesis of Finasteride" University of Texas at Austin, Austin, Texas April 2, 2004.
21. "Educating next generation of Process Chemists in Academia" ACS Petroleum Research Fund Presidential Symposium, 228th meeting of the American Chemical Society, Philadelphia, August 2004.
22. "Green Technology in Pharmaceutical Process Development". Abstracts, 60th Southwest Regional Meeting of the American Chemical Society, Fort Worth, TX, United States, September 29-October 4 (2004), SEPT04-268. Publisher: American Chemical Society, Washington, D. C.
23. "Enantiomeric Ibuprrofen Via Environmentally Benign Temperature Selective Diastereo-Recognition (Tsd)". Abstracts, 60th Southwest Regional Meeting of the American Chemical Society, Fort Worth, Texas, United States, September 29-October 4 (2004), SEPT04-076. Publisher: American Chemical Society, Washington, D. C.
24. "Application of Green Technology in Pharmaceutical Process Development" IUCCP symposium October 18-20, 2004; College Station, Texas.
25. "Green Chemistry in Organic Synthesis" Texas Tech University, Lubbock, Texas February 15, 2005.
26. "Pharmaceutical Process Development" Texas Tech University, Lubbock, Texas February 15, 2005.
27. "Green technology in pharmaceutical process development: Application in the synthesis of Acetaminophen, Ibuprofen and heterocycles" 229th meeting of the American Chemical Society, San Diego, March 2005.
28. "Evolution of a BPH candidate in the Pharmaceutical Drug Development" Chemistry/Biological Sciences, Department of Chemistry, The University of Arizona, April 8, 2005.
29. "Green Chemistry as part of Process Research and Development at Texas A&M-Kingsville". Chemistry/Biological Sciences, Department of Chemistry, The University of Arizona, April 8, 2005.
30. "Commonalities and Differences in Industry and Research Careers" Luis Stokes Alliance for Minority Participation Mini Symposium, Kingsville, Texas, November 4, 2005.
31. "Pharmaceutical Process Research and Development through Green Chemistry at Texas A&M Kingsville, Roger Adams Lab, U. of Illinois. November 14, 2005.
32. "Development of the BPH Drug: Finasteride" Noyes Lab. U. of Illinois. November 14, 2005.
33. "Educating the Next Generation of Process Chemists in an Undergraduate Program" Merck & Co, Rahway, NJ. November 11, 2005.
34. "Green Chemistry: Efficiency in Pharmaceutical Development" Focus Indian Conference on Pharmaceutical R&D Efficiencies-Integrating Global Strategic Partnerships. Hyderabad, India. March 15-17, 2006.
35. "Application of Green Technology in Pharmaceutical Process Development" Current Research Trends and Developments in Heterocyclic Chemistry. Osmania University, Hyderabad, India. March 17-18, 2006.
36. "Essentials of Process Research & Development". University of Texas at Arlington, Arlington, Texas, May 9, 2006.
37. "The Application of Green Technology in Pharmaceutical Process Development". The 4th Annual Congress of International Drug Discovery Science and Technology. Northwestern University, Xi-An, China. May 31-June 2, 2006.
38. "Green Technology in Pharmaceutical Process Development" Developing Chemical Processes for Active Pharmaceutical Ingredients. Scientific Update Conference, N. C. L. Pune, India. December 13-14. 2006.
39. "Green Chemistry" Chemistry & Life. Osmania University College for Women Koti, Hyderabad, India. January 5, 2007.
40. "Green Technology in Pharmaceutical Development" National Conference on Drug Designing & Synthesis. Dr. Ambedkar College, Nagpur, India. Janurary 19-20, 2007.
41. "Total Synthesis of (-)-Galanthamine Hydrobromide" 234th American Chemical Society Conference, Boston (19-23 August), 2007.
42. "Principles of Green Chemistry in API synthesis" Green Chemistry in Conference on Green Chemistry in Drug Synthesis, Department of Chemistry, MNR Degree and PG College Hyderabad India. January 29, 2008,
43. "Application of Green Principles in API Synthesis" National Symposium on Emerging Trends in Medicinal Chemistry, India - A Global Hub" Department of Chemistry, C.K.M. Arts & Science College, Warangal, Hyderabad, India. February 2-3, 2008.
44. "Crystal engineering: Application in the development of Finasteride" Developing Chemical Processes for APIs Scientific Update Conference, February 14-15 2008, Hyderabad, India
45. "De novo synthesis of Rimonabant and its regioisomer" 9th Annual Florida Heterocyclic and Synthetic IUPAC-Sponsored Conference Register online for FloHet IX conference. March 9th - 12th, 2008. Gainesville. Fl.
46. "Green Chemistry and the Global Pharmaceutical Industry" CHEMICAL SCIENCES ROUNDTABLE, May 19-20, 2008. The National Academies, Keck Building. Washington, DC.
47. "Green chemistry in the Generic Pharmaceutical Industry" 2nd International Symposium on Green Processing in the Pharmaceutical & Fine Chemical Industries May 29-30, 2008. Yale University, New Haven, Connecticut, USA.
Past Research:
Industrial experience includes Merck
(7.5 yrs).
Hoechst (7.5 yrs).
Bristol Myers Squibb (2 yrs.).
Developed the synthesis of Propecia™
(hair growth drug) / Proscar™
for BPH (benign prostatic hypertrophy).
Chiral Robinson Annulation.
Synthesis of S-ibuprofen, D-p-hydroxyphenyl glycine, Cromolyn sodium,
Alkyl indanones, Quinazolinones, Amphoteric copolymer, MRI imaging
agents.
Hobbies:
Watching Football (Especially
DALLAS COWBOYS)
