Dr. Scott Gilbertson to give seminar at A&M-Kingsville.
31st Annual Chemistry Olympics brings high school students to A&M-Kingsville.
Dr. Carl E. Wieman delivers the 24th Annual Garland Lecture.
Student Affiliates Chapter of American Chemical Society at TAMUK Ranks in Top Three Percent Nationwide.


 

 


Ph.D. Organic Chemistry, University of Texas at Austin: 1982
M.S. Chemistry, I. I.T. Kanpur, India: 1976
B.S. Chemistry, Calcutta University, India: 1974

Office: N205
Phone: (361) 593-2664
Mailing Address: 920 W. Santa Gertrudis
Kingsville, TX 78363
E-mail address: kfab002@tamuk.edu

Professional Experience

2008-Present   Associate Professor, Texas A&M Kingsville
2007-2008       Senior Vice President. Dr. Reddy’s Laboratories, India.
2006-2007       Vice President, Head of Global Research & Development; Dr. Reddy’s Laboratories, India.
2004-2006       Tenured, Associate Professor
1999-2004       Assistant Professor, Texas A&M University, Kingsville.
1997-1999       Group Leader, Bristol Myers Squibb, Central Process Research
1995-1997       Lead Chemist; Innovator Group, Hoechst.
1994-1995       Staff Chemist, Hoechst-Celanese.
1990-1994       Senior Research Chemist, Hoechst-Celanese.
1988-1990       Research Fellow, Process Research and Development, Merck & Co., Inc.
1983-1988       Senior Research Chemist, Process Research and Development, Merck & Co., Inc.

Curriculum Vitae

Student Presentations

Research Group News Flash

10-02-2004     Pharm Tech - In the Field - Production Process Increases Productivity
07-06-2004     Bridges program offers students road to success
06-15-2004
    Professor to speak at annual symposium ............................................................................................................ . .09-05-2003. . Texas A&M University-Kingsville paves way to Ph.D.s (Corpus Christi Caller Times)
09-03-2003     Chemistry Bridges to Doctoral Grant
10-14-2002     Professor Simplifies Tylenol Production (Corpus Christi Caller Times)
08-01-2002    
A&M-Kingsville has partnership with drug industry (Corpus Christi Caller Times)
07-23-2001     Education Concentrates
(Chemical & Engineering News)
06-21-2001     Graduate Students Intern at Bristol-Meyers Squibb (TAMUK Press Release)
11-01-1999     Renowned chemist sharing his vision
(Corpus Christi Caller Times)

Dr. Bhattacharya's Organic and Environmental Research

Meet Dr. Bhattacharya's Research Group

Current Students Former Students

Course Syllabi:

Advanced Organic Synthesis Physical Organic Chemistry Asymmetric Synthesis Graduate Seminar Green Chemistry CHEM 3323 CHEM 3325

Consultant: 

A. Advisory Board for the Clinton Foundation HIV/AIDS Initiative (CHAI)

B. Member of the National Academies’ Chemical Sciences Roundtable (CSR). This is a committee of advisors that reports its recommendation of the directions of US Science to the US Congress and the President.

C. Member: Panel of Drug Evaluators for Current Drugs (CD). Responsible for the evaluation of drugs, which are being launched worldwide under FDA guidelines.

C. Scientific Process Advisor:

1. Dr Reddy’s Laboratories. Hyderabad, India.
2. PHARM-ECO A Johnson Matthey Company
3. Texas Bio Technology.
4. Bristol Myers Squibb Pharmaceutical Co.
5. Boehringer-Ingelheim Pharmaceutical.
6. Johnson & Johnson Pharmaceutical Research & Development.
7. Ambion.
8. National Advisory Committee, Osmania University, India.

D. Consultant:

1. Senator Kay Bailey Hutchison’s List of Designated Expert in Environmental Chemistry .
2. Corpus Christi Regional Economic Development Corporation

E. Advisory Board Member: Chembiotek, India.

F. Advisor: NIH: SSS-L study section, SBIR/STTR applications in Drug Discovery, Development and Delivery.

G. Director, NIH Texas Bridges to Doctorate Program.

Doctoral Work:
University of Texas at Austin. Asymmetric induction in carbon-carbon bond forming reactions. Kinetic resolutions. Chiral Diels Alder reaction. Asymmetric synthesis of natural product.

Current Research:
Green chemistry.
Designing environmentally benign/waste-free chemistry with special emphasis towards current industrial synthesis and processes utilizing homogeneous and heterogeneous catalyst systems.
Asymmetric synthesis.
Chiral Phase Transfer Catalysis.

Recent Patents:
1. “Process for azole antifungal intermediates” U.S. 6,326,509, Dec.4, 2001.
2. "Method of Producing Organic Compounds in the Presence of Oxyethylene Ether Catalyst and in a Solvent Minimized Environment" issued Nov. 29, 2005. US Patent No. 6,969,775.
3. “Preparation of 4-(2-Bromoethoxy)phenol”. Patent applied in collaboration with Johnson & Johnson (2003 pending).
4. “Method for preparing pyrrolotriazine compounds via amination of pyrroles with in situ generated chloramines” U.S. Pat. Appl. Publ. (2006), 9pp. CODEN: USXXCO US 2006229449 A1 20061012 Patent written in English. Application: US 2006-396888 20060403. Priority: US 2005-668765 20050406. CAN 145:419185 AN 2006:1070156
5. “Process for preparation of 2-amino-5-bromo-4-methyl-3-nitropyridine”. U.S. Pat. Appl. Publ. (2007), 6pp. CODEN: USXXCO US 2007032657 A1 20070208 Patent written in English. Application: US 2006-492730 20060725. Priority: US 2005-705261 20050803. CAN 146:229188 AN 2007:150772
6. "One Pot Reductive Acetaminidation of Aryl Nitro Compounds", issued Feb. 7, 2007. US Patent No. 7,173,152,
7. “Purification process using co-crystal approaches”-US provisional application 60/827,259 on 28 Sep 2006
8. “Preparation of Fosphenytoin sodium” - US 2007/0249563A1

Recent Publications:
1.“Environmentally Friendly Solvent-Free Processes: Application of a Novel Surfactant Induced Dual Catalysis in Henry Reaction” Organic  Process Research Development” 7, 3, 254-258, 2003.
2.“Temperature Selective Diastereo-Recognition (TSD): Enantiomeric Ibuprofen via Environmentally Benign Selective Crystallization”. Organic Process Research Development” 7, 5, 717, 2003.
3. “Benzoin Condensation: Monitoring a Chemical Reaction by High Pressure Liquid Chromatography”. Journal of Chemical Education, 81, 7 1020-2, 2004.
4. “An Efficient Conversion of Nitriles to Amides: Application in the Synthesis of N,N-Diethyl-p-toluamide (DEET™). Tetrahedron Letters 47, 505, 2006.
5.“Surfactant-Mediated Solvent-Free Dealkylative Cleavage of Ethers and Esters and Trans-Alkylations under Neutral Conditions” Tetrahedron Letters 47, 565, 2006.
6.“One-Step Reductive Amidation of Nitro-Arenes: Application in the Synthesis of Aceaminophen™)” Tetrahedron Letters 47, 1861, 2006.
7.“Eco-friendly reductive acetamidation of arylnitro compounds by thioacetate anion through in situ catalytic re-generation: application in the synthesis of acetaminophenTM”
Tetrahedron Letters 47, 3221, 2006.
8.“Remarkable Solvent Effect in Barton-Zard Pyrrole Synthesis: Application in an Efficient One-Step Synthesis of Pyrrole Derivatives”. Tetrahedron Letters, 47, 31, 5421, 2006.
9.“Pseudo-Enzymatic Catalyst-Substrate Interactions in Ion-Pair Mediated Chiral Phase Transfer Catalysis”. Tetrahedron Letters 47, 31, 5581, 2006.
10.“An Efficient Electrophilic N-Amination Utilizing in situ Generated Chloramine Under Phase Transfer Conditions”. Tetrahedron Letters 47, 30, 5341, 2006.
11.“Preparing the Next Generation of Research Scientists” American Chemical Society: Petroleum Research Fund Publication, 2006.
12.“Substrate Modification Approach to Achieve Efficient Resolution: Didesmethylcitalopram-A Key Intermediate for Escitalopram" Organic Process Research Development 11(2), 289-292, 2007.
13.“An Efficient and Impurity-Free Process for Telmisartan: An Antihypertensive Drug”. Organic Process Research & Development, 11(1), 81-85, 2007.
14.“Efficient synthesis of (1R)-[3,5-bis (trifluoromethyl) phenyl] ethanol; a key intermediate for aprepitant, an NK-1 receptor antagonist”. Synthetic Communications. 37: 3439–3446, 2007.
15.“An Alternative Approach to Achieve Enantiopure (3S)-4-Benzyl-3- (4-fluorophenyl)morpholin-2-one: A Key Intermediate of Aprepitant, an NK1 Receptor Antagonist” Organic Process Research & Development. 11(3), 455-457, 2007.
16.“Effect of Solvent on Stereoselectivity in Pd-C (Type-39K) Catalyzed Hydrogena-tion of Methyl 3-oxo-4-aza-5-a-androstene-17-carboxylate- A Key Intermediate for Finasteride and Dutasteride”. Organic Process Research & Development, 11(5); 889-891, 2007.
17."An Alternate Route to 2-Amino-3-Nitro-5-Bromo Picoline: Regioselective Pyridine Synthesis via 2-Nitramino Picoline Intermediate". Organic Process Research & Development, 11(5); 885-888. 2007. [Top ten most downloaded paper in 2007]
18.“An Improved Synthesis of Rimonabant: Anti-obesity Drug” Organic Process Research & Development, 2007. [Top ten most downloaded paper in 2007]
19.“Synthesis of Quinoline Analogs: Search for Anti-malarial Agents” Monatshefte fur Chemie - Chemical Monthly, 2008 (in press).
20.“A Convergent Approach to Synthesis of Aprepitant: A Potent Human NK-1 Receptor Antagonist” Tetrahedron Letters. 48, 8001–8004, 2007.
21."Boric Acid: An Efficient and Environmentally Benign Catalyst for Transesterification of _-Keto Esters” Tetrahedron Letters. 2008 (in press).
22.“Boric Acid Cataylyzed Amidation in the synthesis of Active Pharmaceutical Ingredients” Organic Process Research & Development, 11(6); 1065-1068, 2007.
23.“An Expeditious Synthesis of Ramipril: an Angiotensin Converting Enzyme (ACE) Inhibitor#” Synthetic Communications 2008 (in press).
24.“An Investigation on Key Parameters That Influence the Resolution of Omeprazole Sodium†” Organic Process Research & Development, 2007 (in press).
25.“An alternative total synthesis of (-)-galanthamine hydrobromide” Synthetic Communications 38: 2138–2149, 2008.
26.“Synthesis of Rimonabant Regioisomer” Monatshefte fur Chemie - Chemical Monthly, 2008 (in press).
27.“A Novel Synthesis of Fosphenytoin: Anti-convulsant Prodrug” Synthetic Communications 2008 (in press).
28.“A Non-infringing Synthesis of Simvastatin: HMG-CoA Reductase Inhibitor” Synthetic Communications 2008 (in press).
29.“An Alternative Synthesis of Tadalafil: PDE5 Inhibitor” Synthetic Communications 2008 (in press).
30.“Ab-initio structure determination of anhydrous sodium allendronate from laboratory X-ray diffraction data” Journal of Pharmaceutical Sciences 2008 (accepted).

Past Research:
Industrial experience includes Merck (7.5 yrs).
Hoechst (7.5 yrs).
Bristol Myers Squibb (2 yrs.).
Developed the synthesis of Propecia™ (hair growth drug) / Proscar™ for BPH (benign prostatic hypertrophy).
Chiral Robinson Annulation.
Synthesis of S-ibuprofen, D-p-hydroxyphenyl glycine, Cromolyn sodium, Alkyl indanones, Quinazolinones, Amphoteric copolymer, MRI imaging agents.

Hobbies:
 Watching Football (Especially DALLAS COWBOYS)

 
 
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